Title:
COMPOSITION AND METHOD FOR INHIBITING N-END RULE PATHWAY
Document Type and Number:
WIPO Patent Application WO/2015/102419
Kind Code:
A1
Abstract:
Disclosed are a composition for inhibiting the N-end rule pathway, the composition containing a compound of chemical formula 1 or a pharmaceutically acceptable salt thereof; a method for regulating the N-end rule pathway; and a method and kit for modulating protein denaturation through inhibition of the N-end rule pathway. The composition and method according to the present application can be favorably used to treat or prevent diseases associated with protein denaturation.
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Inventors:
KWON YONG TAE (KR)
LEE MIN JAE (KR)
LEE MIN JAE (KR)
Application Number:
PCT/KR2015/000001
Publication Date:
July 09, 2015
Filing Date:
January 02, 2015
Export Citation:
Assignee:
SNU R&DB FOUNDATION (KR)
UNIV KYUNG HEE UNIV IND COOP GROUP (KR)
UNIV KYUNG HEE UNIV IND COOP GROUP (KR)
International Classes:
A61K31/137; A61P25/16; A61P25/28
Foreign References:
| KR20090059125A | 2009-06-10 |
Other References:
SHASHI SRIRAM ET AL.: "Development and characterization of monomeric N-end rule inhibitors through in vitro model substrates.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 6, 28 March 2013 (2013-03-28), pages 2540 - 2560
MIN JAE LEE ET AL.: "Characterization of arginylation branch of N-end rule pathway in G-protein-mediated proliferation and signaling of cardiomyocytes.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 287, no. 28, 6 July 2012 (2012-07-06), pages 24043 - 24052
MIN JAE LEE ET AL.: "Characterization of arginylation branch of N-end rule pathway in G-protein-mediated proliferation and signaling of cardiomyocytes.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 287, no. 28, 6 July 2012 (2012-07-06), pages 24043 - 24052
Attorney, Agent or Firm:
PARK, Weonmee (KR)
박원미 (KR)
박원미 (KR)
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