Title:
COMPOSITION AND METHODS OF AGING-RELATED AGENT SCREENING AND TARGET ANALYSIS
Document Type and Number:
WIPO Patent Application WO/2024/061369
Kind Code:
A1
Abstract:
Provided is a mammalian derived cell model which can be used in anti-aging drugs. The mammalian-derived extracembryonic trophoblast cell model is an early mammalian-derived extracembryonic stage. The change model of differentiation of cells into exoembryonic trophoblastic cells/organoids and the aging evaluation index system can be used various anti-aging research and target testing, anti-aging drug detection, screening, identification and innovative drugs/natural products Research and development of chemicals, and/or health foods and additives. It is helpful to screen and identify many resistances Candidate targets for aging can be further mechanized and functionally validated for future therapeutic use. The Screening of anti-aging drugs or natural products will produce huge economic and social benefits.
More Like This:
Inventors:
LIU PENGTAO (CN)
FENG ZHEN (CN)
RUAN DEGONG (CN)
LIU FANG (CN)
FENG ZHEN (CN)
RUAN DEGONG (CN)
LIU FANG (CN)
Application Number:
PCT/CN2023/121168
Publication Date:
March 28, 2024
Filing Date:
September 25, 2023
Export Citation:
Assignee:
CENTRE FOR TRANSLATIONAL STEM CELL BIOLOGY LTD (CN)
International Classes:
C12N5/00; C12N5/07; C12N5/10; C12Q1/66
Domestic Patent References:
| WO2021247760A1 | 2021-12-09 |
Foreign References:
| CN114958766A | 2022-08-30 | |||
| CN103048392A | 2013-04-17 |
Other References:
WANG YIMING, JIANG XIANGXIANG, JIA LEI, WU XULUN, WU HAO, WANG YUE, LI QIAN, YU RUOXUAN, WANG HONGMEI, XIAO ZHENYU, LIANG XIAOYAN: "A Single-Cell Characterization of Human Post-implantation Embryos Cultured In Vitro Delineates Morphogenesis in Primary Syncytialization", FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, FRONTIERS MEDIA, CH, vol. 10, CH , XP093149012, ISSN: 2296-634X, DOI: 10.3389/fcell.2022.835445
SONCIN FRANCESCA, MOREY ROBERT, BUI TONY, REQUENA DANIELA F., CHEUNG VIRGINIA CHU, KALLOL SAMPADA, KITTLE RYAN, JACKSON MADELINE G: "Derivation of functional trophoblast stem cells from primed human pluripotent stem cells", STEM CELL REPORTS, CELL PRESS, UNITED STATES, vol. 17, no. 6, 1 June 2022 (2022-06-01), United States , pages 1303 - 1317, XP093149018, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2022.04.013
RUANE PETER T, GARNER TERENCE, PARSONS LYDIA, BABBINGTON PHOEBE A, KIMBER SUSAN J, STEVENS ADAM, WESTWOOD MELISSA, BRISON DANIEL R: "Trophectoderm differentiation to invasive syncytiotrophoblast is induced by endometrial epithelial cells during human embryo implantation", BIORXIV, 2 October 2020 (2020-10-02), XP093149053, Retrieved from the Internet DOI: 10.1101/2020.10.02.323659
XIAO ZHENYU; YAN LONG; LIANG XIAOYAN; WANG HONGMEI: "Progress in deciphering trophoblast cell differentiation during human placentation", CURRENT OPINION IN CELL BIOLOGY, ELSEVIER CURRENT TRENDS, AMSTERDAM, NL, vol. 67, 18 September 2020 (2020-09-18), AMSTERDAM, NL , pages 86 - 91, XP086402925, ISSN: 0955-0674, DOI: 10.1016/j.ceb.2020.08.010
SONCIN FRANCESCA, MOREY ROBERT, BUI TONY, REQUENA DANIELA F., CHEUNG VIRGINIA CHU, KALLOL SAMPADA, KITTLE RYAN, JACKSON MADELINE G: "Derivation of functional trophoblast stem cells from primed human pluripotent stem cells", STEM CELL REPORTS, CELL PRESS, UNITED STATES, vol. 17, no. 6, 1 June 2022 (2022-06-01), United States , pages 1303 - 1317, XP093149018, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2022.04.013
RUANE PETER T, GARNER TERENCE, PARSONS LYDIA, BABBINGTON PHOEBE A, KIMBER SUSAN J, STEVENS ADAM, WESTWOOD MELISSA, BRISON DANIEL R: "Trophectoderm differentiation to invasive syncytiotrophoblast is induced by endometrial epithelial cells during human embryo implantation", BIORXIV, 2 October 2020 (2020-10-02), XP093149053, Retrieved from the Internet
XIAO ZHENYU; YAN LONG; LIANG XIAOYAN; WANG HONGMEI: "Progress in deciphering trophoblast cell differentiation during human placentation", CURRENT OPINION IN CELL BIOLOGY, ELSEVIER CURRENT TRENDS, AMSTERDAM, NL, vol. 67, 18 September 2020 (2020-09-18), AMSTERDAM, NL , pages 86 - 91, XP086402925, ISSN: 0955-0674, DOI: 10.1016/j.ceb.2020.08.010
Attorney, Agent or Firm:
SCIHEAD IP LAW FIRM (CN)
Download PDF: