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Title:
COMPOSITION AND METHODS FOR MODULATION OF VASCULAR STRUCTURE AND/OR FUNCTION
Document Type and Number:
WIPO Patent Application WO2002063961
Kind Code:
B1
Abstract:
The present invention relates to compositions comprising semi-crystalline beta -1-4-N-acetylglucosamine polymers (p-GlcNac) and methods utilizing such polymers modulation of vascular structure and/or function. The compositions and methods disclosed are useful for stimulating, in a p-GlcNac concentration-dependent manner, endothelin-1 release, vasoconstriction, and/or reduction in blood flow out of a breached vessel, as well as for contributing to or effecting cessation of bleeding. The methods of the present invention comprise topical administration of materials comprising semi-crystalline p-GlcNac polymers that are free of proteins, and substantially free of single amino acids as well as other organic and inorganic contaminants, and whose constituent monosaccharide sugars are attached in a beta -1-4 conformation.

Inventors:
VOURNAKIS JOHN N
FINKEILSZTEIN SERGIO
Application Number:
PCT/US2002/003792
Publication Date:
March 06, 2003
Filing Date:
February 08, 2002
Export Citation:
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Assignee:
MARINEPOLYMER TECH INC (US)
International Classes:
A61K9/107; A61K31/715; A61K31/726; A61P7/04; A61P9/14; A61P43/00; C08B37/00; C08B37/08; A61K9/10; (IPC1-7): A01N43/04; A61K31/715; A61K31/70; C07H5/04; C07H1/00; C07H5/06; C07B37/00; C07B37/08
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