Title:
COMPOSITION AND METHODS TO TREAT ECTODERMAL DYSPLASIA 2, CLOUSTON TYPE
Document Type and Number:
WIPO Patent Application WO/2020/237491
Kind Code:
A1
Abstract:
The present technology relates generally to compositions and methods of preventing or treating diseases associated with mutant Cx26, Cx32, and/or Cx30hemichannels. The present technology also relates to administering the anti-Cx26 hemichannel antibodies in effective amounts to treat a subject suffering from, or predisposed to, ectodermal dysplasia 2, Clouston type (OMIM No. 129500), Keratitis-ichthyosis-deafness syndrome (KIDS; OMIM No. 148210), and /or type X Charcot-Marie-Tooth neuropathy (CMTXl; OMIM No. 302800).
Inventors:
MAMMANO FABIO (IT)
YANG GUANG (CN)
ZONTA FRANCESCO (CN)
YANG GUANG (CN)
ZONTA FRANCESCO (CN)
Application Number:
PCT/CN2019/088689
Publication Date:
December 03, 2020
Filing Date:
May 28, 2019
Export Citation:
Assignee:
UNIV SHANGHAI TECH (CN)
International Classes:
C07K16/18; A61P17/00; A61P27/16
Domestic Patent References:
| WO1993011161A1 | 1993-06-10 | |||
| WO2017128880A1 | 2017-08-03 | |||
| WO1999015154A1 | 1999-04-01 | |||
| WO1996040073A2 | 1996-12-19 | |||
| WO2000038651A1 | 2000-07-06 |
Foreign References:
| CN105566495A | 2016-05-11 | |||
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| US5674534A | 1997-10-07 | |||
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Other References:
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MHASKE， P. V.， ET AL.: "The human Cx26-D50A and Cx26-A88V mutations causing keratitis-ichthyosis-deafness syndrome display increased hemichannel activity.", AM. J. PHYSIOL. CELL PHYSIOL., vol. 304, 27 February 2013 (2013-02-27), pages C1150 - C1158, XP055762188
RESSOT， C.， ET AL.: "Connexin32 mutations associated with X-linked Charcot–Marie–Tooth disease show two distinct behaviors: loss of function and altered gating properties.", JOURNAL OF NEUROSCIENCE, vol. 18, no. 11, 1 June 1998 (1998-06-01), pages 4063 - 4075, XP055762200
XU ET AL., FRONT MOL NEUROSCI, vol. 10, 22 September 2017 (2017-09-22), pages 298
KLEOPA, J NEUROSCI, vol. 31, no. 49, 7 December 2011 (2011-12-07), pages 17753 - 17760
LIU ET AL., CLIN EXP DERMATOL, vol. 40, no. 7, October 2015 (2015-10-01), pages 770 - 3
MHASKE ET AL., AM J PHYSIOL CELL PHYSIOL., vol. 304, no. 12, 27 February 2013 (2013-02-27), pages C1150 - 8
RESSOT ET AL., J NEUROSCI, vol. 18, no. 11, 1 June 1998 (1998-06-01), pages 4063 - 75
WEINER: "Liposomes for Protein Delivery: Selecting Manufacture and Development Processes", IMMUNOMETHODS, vol. 4, no. 3, 1994, pages 201 - 9
KUBY, J.: "Immunology", 1997, W.H. FREEMAN & CO.
CLACKSON ET AL., NATURE, vol. 352, 1991, pages 624 - 628
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
HOLLINGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD SCI. USA, vol. 85, 1988, pages 5879 - 5883
HARLOWLANEANTIBODIES: "A Laboratory Manual", 1988, COLD SPRING HARBOR PUBLICATIONS, article "Antibodies"
JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 525
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 327
PRESTA, CURR. OP. STRUCT. BIOL., vol. 2, 1992, pages 593 - 596
AHMEDCHEUNG, FEBSLETTERS, vol. 588, no. 2, 2014, pages 288 - 297
SAXENAWU, FRONTIERS IN IMMUNOLOGY, vol. 7, 2016, pages 580
KOHLER ET AL., NATURE, vol. 256, 1975, pages 495
MARKS ET AL., J. MOL. BIOL., vol. 222, 1991, pages 581 - 597
REDDY, ANN. PHARMACOTHER., vol. 34, no. 7-8, 2000, pages 915 - 923
LICHTENBERG ET AL., METHODS BIOCHEM. ANAL., vol. 33, 1988, pages 337 - 462
ANSELEM ET AL.: "Liposome Technology", 1993, CRC PRESS
KOZARICHRICH, CHEMICAL BIOLOGY, vol. 2, 1998, pages 548 - 552
CHONNCULLIS: "Recent Advances in Liposome Drug Delivery Systems", CURRENT OPINION IN BIOTECHNOLOGY, vol. 6, 1995, pages 698 - 708
GREGORIADIS: "Engineering Liposomes for Drug Delivery: Progress and Problems", TRENDS BIOTECHNOL., vol. 13, no. 12, 1995, pages 527 - 37, XP004207237, DOI: 10.1016/S0167-7799(00)89017-4
MIZGUCHI ET AL., CANCER LETT., vol. 100, 1996, pages 63 - 69
PERKINS ET AL., EUR. J. NUCL. MED., vol. 70, 1985, pages 296 - 301
CARASQUILLO ET AL., J. NUCL. MED., vol. 28, 1987, pages 861 - 870
JALKANEN, M ET AL., J. CELL. BIOL., vol. 101, 1985, pages 976 - 985
JALKANEN, M ET AL., J. CELL. BIOL., vol. 105, 1987, pages 3087 - 3096
WEIR ET AL.: "Handbook of Experimental Immunology", 1986, BLACKWELL SCIENTIFIC PUBLICATIONS
JACOBY ET AL.: "Meth. Enzym.", vol. 34, 1974, ACADEMIC PRESS
BROWN ET AL., MOL. DIVERS, 1995, pages 4 - 12
ROTHSCHILD ET AL., NUCL. ACIDS RES., vol. 24, 1996, pages 351 - 66
ZHANG ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 109, 2012, pages 15728 - 15733
BARBAS ET AL.: "Phage Display: A Laboratory Manual", 2004, COLD SPRING HARBOR PUBLICATIONS
LEE ET AL., NAT. PROTOC., vol. 2, 2007, pages 3001 - 3008
LEFRANC, NUCLEIC ACIDS RES, vol. 43, 2015, pages D413 - D422
LARKIN ET AL., BIOINFORMATICS, vol. 23, 2007, pages 2947 - 2948
TONG ET AL., AMERICAN JOURNAL OF PHYSIOLOGY. CELL PHYSIOLOGY, vol. 300, 2011, pages C1055 - 1064
MHASKE， P. V.， ET AL.: "The human Cx26-D50A and Cx26-A88V mutations causing keratitis-ichthyosis-deafness syndrome display increased hemichannel activity.", AM. J. PHYSIOL. CELL PHYSIOL., vol. 304, 27 February 2013 (2013-02-27), pages C1150 - C1158, XP055762188
RESSOT， C.， ET AL.: "Connexin32 mutations associated with X-linked Charcot–Marie–Tooth disease show two distinct behaviors: loss of function and altered gating properties.", JOURNAL OF NEUROSCIENCE, vol. 18, no. 11, 1 June 1998 (1998-06-01), pages 4063 - 4075, XP055762200
XU ET AL., FRONT MOL NEUROSCI, vol. 10, 22 September 2017 (2017-09-22), pages 298
KLEOPA, J NEUROSCI, vol. 31, no. 49, 7 December 2011 (2011-12-07), pages 17753 - 17760
LIU ET AL., CLIN EXP DERMATOL, vol. 40, no. 7, October 2015 (2015-10-01), pages 770 - 3
MHASKE ET AL., AM J PHYSIOL CELL PHYSIOL., vol. 304, no. 12, 27 February 2013 (2013-02-27), pages C1150 - 8
RESSOT ET AL., J NEUROSCI, vol. 18, no. 11, 1 June 1998 (1998-06-01), pages 4063 - 75
WEINER: "Liposomes for Protein Delivery: Selecting Manufacture and Development Processes", IMMUNOMETHODS, vol. 4, no. 3, 1994, pages 201 - 9
KUBY, J.: "Immunology", 1997, W.H. FREEMAN & CO.
CLACKSON ET AL., NATURE, vol. 352, 1991, pages 624 - 628
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
HOLLINGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD SCI. USA, vol. 85, 1988, pages 5879 - 5883
HARLOWLANEANTIBODIES: "A Laboratory Manual", 1988, COLD SPRING HARBOR PUBLICATIONS, article "Antibodies"
JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 525
RIECHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 327
PRESTA, CURR. OP. STRUCT. BIOL., vol. 2, 1992, pages 593 - 596
AHMEDCHEUNG, FEBSLETTERS, vol. 588, no. 2, 2014, pages 288 - 297
SAXENAWU, FRONTIERS IN IMMUNOLOGY, vol. 7, 2016, pages 580
KOHLER ET AL., NATURE, vol. 256, 1975, pages 495
MARKS ET AL., J. MOL. BIOL., vol. 222, 1991, pages 581 - 597
REDDY, ANN. PHARMACOTHER., vol. 34, no. 7-8, 2000, pages 915 - 923
LICHTENBERG ET AL., METHODS BIOCHEM. ANAL., vol. 33, 1988, pages 337 - 462
ANSELEM ET AL.: "Liposome Technology", 1993, CRC PRESS
KOZARICHRICH, CHEMICAL BIOLOGY, vol. 2, 1998, pages 548 - 552
CHONNCULLIS: "Recent Advances in Liposome Drug Delivery Systems", CURRENT OPINION IN BIOTECHNOLOGY, vol. 6, 1995, pages 698 - 708
GREGORIADIS: "Engineering Liposomes for Drug Delivery: Progress and Problems", TRENDS BIOTECHNOL., vol. 13, no. 12, 1995, pages 527 - 37, XP004207237, DOI: 10.1016/S0167-7799(00)89017-4
MIZGUCHI ET AL., CANCER LETT., vol. 100, 1996, pages 63 - 69
PERKINS ET AL., EUR. J. NUCL. MED., vol. 70, 1985, pages 296 - 301
CARASQUILLO ET AL., J. NUCL. MED., vol. 28, 1987, pages 861 - 870
JALKANEN, M ET AL., J. CELL. BIOL., vol. 101, 1985, pages 976 - 985
JALKANEN, M ET AL., J. CELL. BIOL., vol. 105, 1987, pages 3087 - 3096
WEIR ET AL.: "Handbook of Experimental Immunology", 1986, BLACKWELL SCIENTIFIC PUBLICATIONS
JACOBY ET AL.: "Meth. Enzym.", vol. 34, 1974, ACADEMIC PRESS
BROWN ET AL., MOL. DIVERS, 1995, pages 4 - 12
ROTHSCHILD ET AL., NUCL. ACIDS RES., vol. 24, 1996, pages 351 - 66
ZHANG ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 109, 2012, pages 15728 - 15733
BARBAS ET AL.: "Phage Display: A Laboratory Manual", 2004, COLD SPRING HARBOR PUBLICATIONS
LEE ET AL., NAT. PROTOC., vol. 2, 2007, pages 3001 - 3008
LEFRANC, NUCLEIC ACIDS RES, vol. 43, 2015, pages D413 - D422
LARKIN ET AL., BIOINFORMATICS, vol. 23, 2007, pages 2947 - 2948
TONG ET AL., AMERICAN JOURNAL OF PHYSIOLOGY. CELL PHYSIOLOGY, vol. 300, 2011, pages C1055 - 1064
Attorney, Agent or Firm:
J.Z.M.C. PATENT AND TRADEMARK LAW OFFICE (GENERAL PARTNERSHIP) (CN)
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