COMPOSITION FOR NERVE-CELL OR ENDOTHELIAL-CELL REGENERATION COMPRISING A NINJURIN ACTION SUPPRESSING AGENT

Title:

COMPOSITION FOR NERVE-CELL OR ENDOTHELIAL-CELL REGENERATION COMPRISING A NINJURIN ACTION SUPPRESSING AGENT

Document Type and Number:

WIPO Patent Application WO/2012/121529

Kind Code:

A3

Abstract:

The present invention relates to a composition for nerve-cell or endothelial-cell regeneration comprising a ninjurin action suppressing agent as an active ingredient. More specifically, provided is a pharmaceutical composition for preventing and/or treating erectile dysfunction comprising a ninjurin action suppressing agent. The ninjurin action suppressing agent of the present invention has a nerve-cell and/or endothelial-cell regeneration action and can be used to prevent and/or treat erectile dysfunction by inducing the growth of nerve-cells and/or endothelial-cells in the penis. Moreover, the present invention can be expected to have a relatively sustained therapeutic effect by fundamentally treating nerves and blood vessel structures which have become abnormal.

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Inventors:

KIM KYU-WON (KR)
AHN BUM JU (KR)
SUH JUN-KYU (KR)
RYU JI-KAN (KR)
KIM WOO JEAN (KR)
YIN GUO NAN (KR)

Application Number:

PCT/KR2012/001621

Publication Date:

December 13, 2012

Filing Date:

March 05, 2012

Export Citation:

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Assignee:

SNU R&DB FOUNDATION (KR)
INHA IND PARTNERSHIP INST (KR)
KIM KYU-WON (KR)
AHN BUM JU (KR)
SUH JUN-KYU (KR)
RYU JI-KAN (KR)
KIM WOO JEAN (KR)
YIN GUO NAN (KR)

International Classes:

A61K39/395; A61K35/12; A61K38/17; A61P15/10; A61K39/00

Foreign References:

US20100310568A1	2010-12-09
KR20100065953A	2010-06-17

Other References:

JAE WHA KIM ET AL.: "Up-regulation ofninjurin expression in human in hepatocellular carcinoma associated with cirrhosis and chronic viral hepatitis", MOLECULES AND CELLS, vol. 11, no. 2, 2001, pages 151 - 157
TOSHIYUKI ARAKI ET AL.: "Mechanism ofhomophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 34, 1997, pages 21373 - 21380

Attorney, Agent or Firm:

ERUUM PATENT LAW FIRM (1005-8 Daechi-dong Kangnam-gu, Seoul 135-851, KR)

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