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Title:
COMPOSITION FOR ORAL DELIVERY OF SORAFENIB AND USE OF SAID COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2019/208617
Kind Code:
A1
Abstract:
[Problem] To provide a pharmaceutical composition effective in fibrosis. [Solution] Provided is: a composition containing a copolymer that includes a sorafenib and poly(ethylene glycol) segment, as well as a segment based on polystyrene having a cyclic nitroxide radical and a tri(alkoxysilane) each randomly in a side chain, the copolymer optionally containing a tetra(alkoxy)silane; or nanoparticles formed from said composition.

Inventors:
NAGASAKI, Yukio (1-1-1 Tennodai, Tsukuba-sh, Ibaraki 77, 〒3058577, JP)
TRAN, Hao Thi (1-1-1 Tennodai, Tsukuba-sh, Ibaraki 77, 〒3058577, JP)
VONG, Binh Long (1-1-1 Tennodai, Tsukuba-sh, Ibaraki 77, 〒3058577, JP)
NISHIKAWA, Yuji (1-1 Midorigaoka Higashi 2-jo 1-chome, Asahikawa-sh, Hokkaido 10, 〒0788510, JP)
SHASHNI, Babita (1-1-1 Tennodai, Tsukuba-sh, Ibaraki 77, 〒3058577, JP)
Application Number:
JP2019/017366
Publication Date:
October 31, 2019
Filing Date:
April 24, 2019
Export Citation:
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Assignee:
UNIVERSITY OF TSUKUBA (1-1-1, Tennodai Tsukuba-sh, Ibaraki 77, 〒3058577, JP)
ASAHIKAWA MEDICAL UNIVERSITY (1-1 Midorigaoka Higashi 2-jo 1-chome, Asahikawa-shi Hokkaido, 10, 〒0788510, JP)
International Classes:
A61K31/44; A61K9/51; A61K31/787; A61K31/795; A61K47/24; A61K47/34; A61P35/00
Other References:
VONG, L. B. ET AL.: "Newly designed silica- containing redox nanoparticles for oral delivery of novel TOP2 catalytic inhibitor for treating colon cancer", ADV. HEALTHC. MATER., vol. 6, no. 20, 24 July 2017 (2017-07-24) - October 2017 (2017-10-01), pages 1700428, XP055647329
WANG, X. Q. ET AL.: "Bioavailability and pharmacokinetics of sorafenib suspension, nanoparticles and nanomatrix for oral administration to rat", INT. J. PHARM., vol. 419, no. 1 , 2, 9 August 2011 (2011-08-09), pages 339 - 346, XP028306649, DOI: 10.1016/j.ijpharm.2011.08.003
Attorney, Agent or Firm:
PATENT PROFESSION CORPORATION ODAJIMA PATENT OFFICE (Nagatacho Bldg, 4-3 Nagatacho 2-chome, Chiyoda-k, Tokyo 14, 〒1000014, JP)
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