Title:
COMPOSITION FOR PREDICTING RESPONSE TO STANDARD PREOPERATIVE CHEMORADIATION THERAPY AND PROGNOSIS FOLLOWING TREATMENT, AND METHOD AND COMPOSITION FOR PREDICTING PATIENTS WITH VERY UNSATISFACTORY PROGNOSES FOLLOWING STANDARD THERAPY
Document Type and Number:
WIPO Patent Application WO/2021/101339
Kind Code:
A1
Abstract:
The present invention relates to a biomarker composition for predicting the prognosis of a cancer patient, the biomarker composition including a first molecular subtype or a protein transcribed and translated from the first molecular subtype. The present invention also relates to a biomarker composition for predicting the prognosis of a cancer patient, the biomarker composition further including a second molecular subtype or a protein transcribed and translated from the second molecular subtype.
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Inventors:
PAIK SOONMYUNG (KR)
MIN BYUNG SOH (KR)
KATHERINE POGUE-GEILE (US)
MIN BYUNG SOH (KR)
KATHERINE POGUE-GEILE (US)
Application Number:
PCT/KR2020/016526
Publication Date:
May 27, 2021
Filing Date:
November 20, 2020
Export Citation:
Assignee:
NOVOMICS CO LTD (KR)
International Classes:
C12Q1/6886; G01N33/574
Domestic Patent References:
| WO2013109613A1 | 2013-07-25 |
Foreign References:
| US20130345077A1 | 2013-12-26 |
Other References:
ZARAVINOS APOSTOLOS, ROUFAS CONSTANTINOS, NAGARA MAJDI, DE LUCAS MORENO BEATRIZ, OBLOVATSKAYA MARIA, EFSTATHIADES CHRISTODOULOS, D: "Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer", JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, vol. 38, no. 1, 1 December 2019 (2019-12-01), XP055813738, DOI: 10.1186/s13046-019-1372-z
KALADY, M.F. ; DEJULIUS, K. ; CHURCH, J.M. ; LAVERY, I.C. ; FAZIO, V.W. ; ISHWARAN, H.: "Gene Signature Is Associated with Early Stage Rectal Cancer Recurrence", JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS., COLLEGE, CHICAGO, IL., US, vol. 211, no. 2, 1 August 2010 (2010-08-01), US, pages 187 - 195, XP027180770, ISSN: 1072-7515
ROMAIN BENOÎT; NEUVILLE AGNÈS; MEYER NICOLAS; BRIGAND CÉCILE; ROHR SERGE; SCHNEIDER ANNE; GAUB MARIE-PIERRE; GUENOT DOMINIQUE: "Allelotyping identification of genomic alterations in rectal chromosomally unstable tumors without preoperative treatment", BMC CANCER, BIOMED CENTRAL, LONDON, GB, vol. 10, no. 1, 18 October 2010 (2010-10-18), LONDON, GB, pages 561, XP021075384, ISSN: 1471-2407, DOI: 10.1186/1471-2407-10-561
KOHLERMILSTEIN, EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 6, 1976, pages 511 - 519
CLACKSON ET AL., NATURE, vol. 352, 1991, pages 624 - 628
MARKS ET AL., J. MOL. BIOL., vol. 222, no. 58, 1991, pages 1 - 597
NIELSEN PEEGHOLM MBERG RHBUCHARDT O: "Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide", SCIENCE, vol. 254, no. 5037, December 1991 (1991-12-01), pages 1497 - 1500, XP002912953, DOI: 10.1126/science.1962210
BOCK LC ET AL., NATURE, vol. 355, no. 6360, 1992, pages 5646
HOPPE-SEYLER FBUTZ K: "Peptide aptamers: powerful new tools for molecular medicine", J MOL MED, vol. 78, no. 8, 2000, pages 42630, XP002413234, DOI: 10.1007/s001090000140
COHEN BACOLAS PBRENT R: "An artificial cell-cycle inhibitor isolated from a combinatorial library", PROC NATL ACAD SCI USA., vol. 95, no. 24, 1998, pages 142727
See also references of EP 4063522A4
KALADY, M.F. ; DEJULIUS, K. ; CHURCH, J.M. ; LAVERY, I.C. ; FAZIO, V.W. ; ISHWARAN, H.: "Gene Signature Is Associated with Early Stage Rectal Cancer Recurrence", JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS., COLLEGE, CHICAGO, IL., US, vol. 211, no. 2, 1 August 2010 (2010-08-01), US, pages 187 - 195, XP027180770, ISSN: 1072-7515
ROMAIN BENOÎT; NEUVILLE AGNÈS; MEYER NICOLAS; BRIGAND CÉCILE; ROHR SERGE; SCHNEIDER ANNE; GAUB MARIE-PIERRE; GUENOT DOMINIQUE: "Allelotyping identification of genomic alterations in rectal chromosomally unstable tumors without preoperative treatment", BMC CANCER, BIOMED CENTRAL, LONDON, GB, vol. 10, no. 1, 18 October 2010 (2010-10-18), LONDON, GB, pages 561, XP021075384, ISSN: 1471-2407, DOI: 10.1186/1471-2407-10-561
KOHLERMILSTEIN, EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 6, 1976, pages 511 - 519
CLACKSON ET AL., NATURE, vol. 352, 1991, pages 624 - 628
MARKS ET AL., J. MOL. BIOL., vol. 222, no. 58, 1991, pages 1 - 597
NIELSEN PEEGHOLM MBERG RHBUCHARDT O: "Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide", SCIENCE, vol. 254, no. 5037, December 1991 (1991-12-01), pages 1497 - 1500, XP002912953, DOI: 10.1126/science.1962210
BOCK LC ET AL., NATURE, vol. 355, no. 6360, 1992, pages 5646
HOPPE-SEYLER FBUTZ K: "Peptide aptamers: powerful new tools for molecular medicine", J MOL MED, vol. 78, no. 8, 2000, pages 42630, XP002413234, DOI: 10.1007/s001090000140
COHEN BACOLAS PBRENT R: "An artificial cell-cycle inhibitor isolated from a combinatorial library", PROC NATL ACAD SCI USA., vol. 95, no. 24, 1998, pages 142727
See also references of EP 4063522A4
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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