Title:
COMPOSITION FOR PREDICTING SULFONYLUREA DEPENDENCE BY USING THADA MARKER, AND PREDICTION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/080651
Kind Code:
A1
Abstract:
The present invention relates to a composition and a method, which can predict sulfonylurea dependence of diabetes patients by identifying: a first variant selected from the group consisting of a variant at base 43801878 (A allele), a variant at base 43801909 (T allele), a variant at base 43776463 (C allele), a variant at base 43625187 (C allele), a variant at base 43520160 (C allele) and a variant at base 43805692 (G allele) of chromosome 2 of GRCH37/hg19 of THADA armadillo repeat containing (THADA); or a second variant which reduces the function of the THADA armadillo repeat containing (THADA) protein, and of which the allele frequency is 5% or less.
Inventors:
JUNG HYE SEUNG (KR)
Application Number:
PCT/KR2023/015065
Publication Date:
April 18, 2024
Filing Date:
September 27, 2023
Export Citation:
Assignee:
SEOUL NAT UNIV HOSPITAL (KR)
International Classes:
C12Q1/6883
Foreign References:
| JP2018515128A | 2018-06-14 | |||
| JP2016067323A | 2016-05-09 |
Other References:
SWEN J.J., GUCHELAAR H.J., BAAK-PABLO R.F., ASSENDELFT W.J.J., WESSELS J.A.M.: "Genetic risk factors for type 2 diabetes mellitus and response to sulfonylurea treatment", PHARMACOGENETICS AND GENOMICS, LIPPINCOTT WILLIAMS & WILKINS, PHILADELPHIA, PA, US, vol. 21, no. 8, 1 August 2011 (2011-08-01), US , pages 461 - 468, XP009554443, ISSN: 1744-6872, DOI: 10.1097/FPC.0b013e3283478173
WEIPING SUN: "Integrative analysis of super enhancer SNPs for type 2 diabetes", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 13, no. 1, 31 January 2018 (2018-01-31), US , pages e0192105, XP093158073, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0192105
JOSEPHINE H. LI: "A Polygenic Score for Type 2 Diabetes Risk Is Associated With Both the Acute and Sustained Response to Sulfonylureas", DIABETES, AMERICAN DIABETES ASSOCIATION :, vol. 70, no. 1, 1 January 2021 (2021-01-01), pages 293 - 300, XP093158075, ISSN: 0012-1797, DOI: 10.2337/db20-0530
WEIPING SUN: "Integrative analysis of super enhancer SNPs for type 2 diabetes", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 13, no. 1, 31 January 2018 (2018-01-31), US , pages e0192105, XP093158073, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0192105
JOSEPHINE H. LI: "A Polygenic Score for Type 2 Diabetes Risk Is Associated With Both the Acute and Sustained Response to Sulfonylureas", DIABETES, AMERICAN DIABETES ASSOCIATION :, vol. 70, no. 1, 1 January 2021 (2021-01-01), pages 293 - 300, XP093158075, ISSN: 0012-1797, DOI: 10.2337/db20-0530
Attorney, Agent or Firm:
KIYUL IP LAW FIRM (KR)
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