Title:
COMPOSITION FOR PREVENTING ADHESION
Document Type and Number:
WIPO Patent Application WO/2016/114355
Kind Code:
A1
Abstract:
The present invention provides a composition for preventing adhesion using a combination of (a) a monovalent metal salt of low-endotoxin alginic acid, (b) carboxymethylcellulose or a pharmacologically acceptable salt thereof, and (c) cells. A composition for preventing adhesion having a high adhesion-preventing effect is thereby provided.
Inventors:
ITO TAICHI (JP)
KOKUDO NORIHIRO (JP)
NISHIYAMA TORU (JP)
SHIMIZU ATSUSHI (JP)
SHIMIZU SATOSHI (JP)
ISAJI MITSUKO (JP)
KOKUDO NORIHIRO (JP)
NISHIYAMA TORU (JP)
SHIMIZU ATSUSHI (JP)
SHIMIZU SATOSHI (JP)
ISAJI MITSUKO (JP)
Application Number:
PCT/JP2016/050998
Publication Date:
July 21, 2016
Filing Date:
January 14, 2016
Export Citation:
Assignee:
UNIV TOKYO (JP)
MOCHIDA PHARM CO LTD (JP)
MOCHIDA PHARM CO LTD (JP)
International Classes:
A61L31/00; A61K9/06; A61K9/08; A61K9/14; A61K9/70; A61K35/15; A61K35/28; A61K47/36; A61K47/38; A61P1/16; A61P41/00
Domestic Patent References:
| WO2014115776A1 | 2014-07-31 | |||
| WO2001005370A1 | 2001-01-25 |
Foreign References:
| JP2007075425A | 2007-03-29 | |||
| JP2005000608A | 2005-01-06 | |||
| JP2008515927A | 2008-05-15 |
Other References:
KIM T. ET AL.: "A randomized, multi-center, clinical trial to assess the efficacy and safety of alginate carboxymethylcellulose hyaluronic acid compared to carboxymethylcellulose hyaluronic acid to prevent postoperative intrauterine adhesion.", JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY, vol. 19, no. 6, 2012, pages 731 - 736, ISSN: 1553-4650
CHATURVEDI A.A. ET AL.: "Prevention of postsurgical adhesions using an ultrapure alginate-based gel.", BRITISH JOURNAL OF SURGERY, vol. 100, no. 7, 2013, pages 904 - 910, ISSN: 0007-1323
NAMBA J. ET AL.: "Modulation of peritendinous adhesion formation by alginate solution in a rabbit flexor tendon model.", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART B, APPLIED BIOMATERIALS ., vol. 80, no. 1, 2007, pages 273 - 279, ISSN: 1552-4973
KUNIO KAWANISHI ET AL., FUKUMAKU SAIBO SHEET NO KAIHATSU TO JUTSUGO CHOKAN YUCHAKU MODEL NI OKERU YUCHAKU BOSHI KOKA NO KENTO, vol. 32, 2012, pages 72 - 73, ISSN: 0911-4491
KUNIO KAWANISHI ET AL.: "Fukumaku Saibo Sheet no Kaihatsu to Jutsugo Chokan Yuchaku Model ni Okeru Yuchaku Boshi Koka no Kento", JOURNAL OF THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE, vol. 11, 2012, pages 199, ISSN: 1347-7919
KIM Y.D. ET AL.: "Effects of human adipose- derived stem cells on the regeneration of damaged visceral pleural mesothelial cells: a morphological study in a rabbit model.", INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, vol. 19, no. 3, 2014, pages 363 - 367, ISSN: 1569-9293
HIROYOSHI MIZOTE ET AL.: "POSTOPERATIVE ADHESIVE ILEUS", THE JOURNAL OF THE JAPAN SURGICAL ASSOCIATION, vol. 40, no. 1, 1979, pages 131 - 138, ISSN: 0386-9776
CHATURVEDI A.A. ET AL.: "Prevention of postsurgical adhesions using an ultrapure alginate-based gel.", BRITISH JOURNAL OF SURGERY, vol. 100, no. 7, 2013, pages 904 - 910, ISSN: 0007-1323
NAMBA J. ET AL.: "Modulation of peritendinous adhesion formation by alginate solution in a rabbit flexor tendon model.", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART B, APPLIED BIOMATERIALS ., vol. 80, no. 1, 2007, pages 273 - 279, ISSN: 1552-4973
KUNIO KAWANISHI ET AL., FUKUMAKU SAIBO SHEET NO KAIHATSU TO JUTSUGO CHOKAN YUCHAKU MODEL NI OKERU YUCHAKU BOSHI KOKA NO KENTO, vol. 32, 2012, pages 72 - 73, ISSN: 0911-4491
KUNIO KAWANISHI ET AL.: "Fukumaku Saibo Sheet no Kaihatsu to Jutsugo Chokan Yuchaku Model ni Okeru Yuchaku Boshi Koka no Kento", JOURNAL OF THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE, vol. 11, 2012, pages 199, ISSN: 1347-7919
KIM Y.D. ET AL.: "Effects of human adipose- derived stem cells on the regeneration of damaged visceral pleural mesothelial cells: a morphological study in a rabbit model.", INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, vol. 19, no. 3, 2014, pages 363 - 367, ISSN: 1569-9293
HIROYOSHI MIZOTE ET AL.: "POSTOPERATIVE ADHESIVE ILEUS", THE JOURNAL OF THE JAPAN SURGICAL ASSOCIATION, vol. 40, no. 1, 1979, pages 131 - 138, ISSN: 0386-9776
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
Kobayashi 浩 (JP)
Kobayashi 浩 (JP)
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