Title:
COMPOSITION FOR PREVENTING OR AMELIORATING LOSS OF HAIR AND GRAYING OF HAIR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/122668
Kind Code:
A1
Abstract:
The present invention provides a composition for preventing or ameliorating newly occurring loss of hair and a composition for preventing or ameliorating graying of hair. More specifically, the present invention provides a composition containing, as an active ingredient, an agent for stabilizing the expression of collagen XVII, preferably a collagen XVII decomposition inhibitor such as an ELANE inhibitor, or an agent for promoting the repairing of DNA or an agent for inhibiting the damage of DNA. When a composition containing, as an active ingredient, a collagen XVII decomposition inhibitor, such as an ELANE inhibitor, is administered to a mammal, an advantageous effect for preventing the loss of hair and the graying of hair can be produced. As the ELANE inhibitor, the collagen XVII decomposition inhibitor or the agent for promoting the repairing of DNA, a low-molecular-weight compound, a polypeptide, a protein, an antibody, or a nucleic acid drug such as an antisense oligonucleotide and siRNA can be used. Also provided is a method for screening for a substance that is effective for the prevention of the loss of hair and the graying of hair.
Inventors:
NISHIMURA EMI (JP)
MATSUMURA HIROYUKI (JP)
MATSUMURA HIROYUKI (JP)
Application Number:
PCT/JP2017/000610
Publication Date:
July 20, 2017
Filing Date:
January 11, 2017
Export Citation:
Assignee:
NAT UNIV CORP TOKYO MEDICAL & DENTAL UNIV (JP)
International Classes:
A61K45/00; A61K8/97; A61K31/222; A61K31/506; A61K31/7088; A61K31/713; A61K36/04; A61K36/05; A61K36/14; A61K36/18; A61K36/185; A61K36/23; A61K36/28; A61K36/30; A61K36/424; A61K36/47; A61K36/48; A61K36/488; A61K36/489; A61K36/53; A61K36/54; A61K36/60; A61K36/718; A61K36/738; A61K36/74; A61K36/82; A61K38/55; A61K39/395; A61K48/00; A61P17/00; A61P17/14; A61P43/00; A61Q5/00; A61Q7/00; C12Q1/37
Domestic Patent References:
| WO1999062465A1 | 1999-12-09 | |||
| WO2013031003A1 | 2013-03-07 |
Foreign References:
| JPS62142108A | 1987-06-25 | |||
| JP2011148792A | 2011-08-04 |
Other References:
SHINTARO TANIMURA ET AL.: "Hair follicle stem cells provide a functional niche for melanocyte stem cells", CELL STEM CELL, vol. 8, no. 2, 2011, pages 177 - 87, XP028137653
SEIBERG M.: "Age-induced hair greying - the multiple effects of oxidative stress", INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, vol. 35, no. 6, 2013, pages 532 - 8, XP055086173
SYLVIE VERRAES ET AL.: "Respective contribution of neutrophil elastase and matrix metalloproteinase 9 in the degradation of BP180 (type XVII collagen) in human bullous pemphigoid", THE JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 117, no. 5, 2001, pages 1091 - 6, XP055400163
ANNE-LAURE LABROUSSE ET AL.: "The metalloprotease-directed shedding of BP 180 (collagen XVII) from human keratinocytes in culture is unaffected by ceramide and cell - matrix interaction", EUROPEAN JOURNAL OF DERMATOLOGY, vol. 12, no. 3, 2002, pages 240 - 246, XP009512092, ISSN: 1167-1122
CLAUS-WERNER FRANZKE ET AL.: "Shedding of collagen XVII/BP180 in skin depends on both ADAM10 and ADAM9", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 35, 2009, pages 23386 - 96, XP055400175
SHIGEATSU ENDO: "Sivelestat Sodium Hydrate", PHARMA MEDICA, vol. 21, no. 1, 2003, pages 124 - 125, XP009512147, ISSN: 0289-5803
HONGYAN JIANG ET AL.: "Rac/Rho pathway regulates actin depolymerization induced by aminoglycoside antibiotics", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 83, no. 8, 2006, pages 1544 - 51, XP055400178
MUIJSERS R. B. R. ET AL.: "Apocynin inhibits peroxynitrite formation by murine macrophages", BRITISH JOURNAL OF PHARMACOLOGY, vol. 130, no. 4, 2000, pages 932 - 6, XP055400181
PANAGIOTA A. SOTIROPOULOU ET AL.: "Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage- induced cell death", NATURE CELL BIOLOGY, vol. 12, no. 6, 2010, pages 572 - 82, XP055400183
SEIBERG M.: "Age-induced hair greying - the multiple effects of oxidative stress", INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, vol. 35, no. 6, 2013, pages 532 - 8, XP055086173
SYLVIE VERRAES ET AL.: "Respective contribution of neutrophil elastase and matrix metalloproteinase 9 in the degradation of BP180 (type XVII collagen) in human bullous pemphigoid", THE JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 117, no. 5, 2001, pages 1091 - 6, XP055400163
ANNE-LAURE LABROUSSE ET AL.: "The metalloprotease-directed shedding of BP 180 (collagen XVII) from human keratinocytes in culture is unaffected by ceramide and cell - matrix interaction", EUROPEAN JOURNAL OF DERMATOLOGY, vol. 12, no. 3, 2002, pages 240 - 246, XP009512092, ISSN: 1167-1122
CLAUS-WERNER FRANZKE ET AL.: "Shedding of collagen XVII/BP180 in skin depends on both ADAM10 and ADAM9", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 35, 2009, pages 23386 - 96, XP055400175
SHIGEATSU ENDO: "Sivelestat Sodium Hydrate", PHARMA MEDICA, vol. 21, no. 1, 2003, pages 124 - 125, XP009512147, ISSN: 0289-5803
HONGYAN JIANG ET AL.: "Rac/Rho pathway regulates actin depolymerization induced by aminoglycoside antibiotics", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 83, no. 8, 2006, pages 1544 - 51, XP055400178
MUIJSERS R. B. R. ET AL.: "Apocynin inhibits peroxynitrite formation by murine macrophages", BRITISH JOURNAL OF PHARMACOLOGY, vol. 130, no. 4, 2000, pages 932 - 6, XP055400181
PANAGIOTA A. SOTIROPOULOU ET AL.: "Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage- induced cell death", NATURE CELL BIOLOGY, vol. 12, no. 6, 2010, pages 572 - 82, XP055400183
Attorney, Agent or Firm:
ITO, Katsuhiro et al. (JP)
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