Title:
COMPOSITION FOR PREVENTING, AMELIORATING OR TREATING LIVER CANCER OR GASTRIC CANCER CONTAINING SINENSETIN AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2019/088749
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing, ameliorating or treating liver cancer or gastric cancer containing sinensetin as an active ingredient. Specifically, the present invention relates to a pharmaceutical composition, a functional food composition and a functional feed composition for preventing, ameliorating or treating liver cancer or gastric cancer and for inhibiting metastasis, containing sinensetin as an active ingredient, or sinensetin and cisplatin as active ingredients. As a result of containing sinensetin as an active ingredient, the composition of the present invention can effectively prevent, ameliorate, or treat liver cancer or gastric cancer by inducing the death of liver cancer cells or gastric cancer cells without significantly affecting normal cells, and can effectively inhibit metastasis of liver cancer or gastric cancer by inhibiting the mobility of liver cancer cells or gastric cancer cells. Particularly, a composition containing sinensetin together with cisplatin as active ingredients has superior effects of killing gastric cancer cells and inhibiting the mobility thereof due to synergy of the two ingredients, and thus can prevent, ameliorate or treat gastric cancer more effectively and inhibit metastasis.
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Inventors:
KIM GON SUP (KR)
LEE SANG JUN (KR)
HER JUNG DOO (KR)
LEE SANG JUN (KR)
HER JUNG DOO (KR)
Application Number:
PCT/KR2018/013230
Publication Date:
May 09, 2019
Filing Date:
November 02, 2018
Export Citation:
Assignee:
NAT UNIV GYEONGSANG IACF (KR)
KOREA RES INST CHEMICAL TECH (KR)
KOREA RES INST CHEMICAL TECH (KR)
International Classes:
A61K31/352; A23K20/121; A23L33/10; A61K31/282
Foreign References:
| KR20170014595A | 2017-02-08 | |||
| KR20170014597A | 2017-02-08 |
Other References:
ZHANG, J.: "Chemopreventive effect of flavonoids from Ougan Citrus reticulata cv. Suavissima) fruit against cancer cell proliferation and migrat ion", JOURNAL OF FUNCTIONAL FOODS, 2014, pages 10 5 11 - 519, XP55612668
DONG, Y. O: "Effects of sinensetin on proliferation and apoptosis of human gastric cancer AGS cells", ZHONGGUO ZHONG YAO ZA ZHI, vol. 36, no. 6, 2011, pages 790 - 794
AT-SUEDE, F. S. R.: "Optimization of cat's whiskers tea (Orthosiphon stamineus) using supercritical carbon dioxide and selective chemotherapeutic potential against prostate cancer cells", EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2014, pages 1 - 15, XP55612670
LEE, S. H.: "Flavonoids of Korean Citrus aurantium L. induce apoptosis via intrinsic pathway in human hepatoblastoma HepG2 cells", PHYTOTHERAPY RESEARCH, vol. 29, 2015, pages 1940 - 1949, XP55612671
DONG, Y. O: "Effects of sinensetin on proliferation and apoptosis of human gastric cancer AGS cells", ZHONGGUO ZHONG YAO ZA ZHI, vol. 36, no. 6, 2011, pages 790 - 794
AT-SUEDE, F. S. R.: "Optimization of cat's whiskers tea (Orthosiphon stamineus) using supercritical carbon dioxide and selective chemotherapeutic potential against prostate cancer cells", EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2014, pages 1 - 15, XP55612670
LEE, S. H.: "Flavonoids of Korean Citrus aurantium L. induce apoptosis via intrinsic pathway in human hepatoblastoma HepG2 cells", PHYTOTHERAPY RESEARCH, vol. 29, 2015, pages 1940 - 1949, XP55612671
Attorney, Agent or Firm:
HYUNMOON PATENT&LAW FIRM (KR)
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