Title:
COMPOSITION FOR PREVENTING, AMELIORATING OR TREATING POLYCYSTIC OVARY SYNDROME-RELATED DISEASES COMPRISING ECKLONIA CAVA EXTRACT AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2018/190630
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing, ameliorating or treating polycystic ovary syndrome-related diseases comprising an Ecklonia cava extract as an active ingredient. The Ecklonia cava extract, which is an active ingredient of the present invention, has an activity of regulating the production of androgen dehydroepiandrosterone (DHEA), an effect of reducing the luteinizing hormone/follicle stimulating hormone ratio in the blood, an effect of increasing follicular stimulating hormone in the blood, and an effect of reducing blood testosterone and the number of ovarian follicular cysts. Therefore, the Ecklonia cava extract can be effectively used for preventing, ameliorating or treating one or more diseases selected from hyperandrogenism, amenorrhea, hypomenorrhea, dysfunctional uterine bleeding, premature menopause, infertility, ovarian failure, and endometriosis, which are polycystic ovary syndrome-related diseases.
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Inventors:
LEE HYE WON (KR)
KO BYOUNG SEOB (KR)
YANG HYUN (KR)
PYUN BO-JEONG (KR)
KO BYOUNG SEOB (KR)
YANG HYUN (KR)
PYUN BO-JEONG (KR)
Application Number:
PCT/KR2018/004237
Publication Date:
October 18, 2018
Filing Date:
April 11, 2018
Export Citation:
Assignee:
KOREA INST ORIENTAL MEDICINE (KR)
International Classes:
A61K36/03; A23L33/105
Foreign References:
| KR101613448B1 | 2016-05-02 | |||
| KR20160094830A | 2016-08-10 |
Other References:
LEE, S. -H.: "Effects of brown alga, Ecklonia cava on glucose and lipid metabolism in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus", FOOD AND CHEMICAL TOXICOLOGY, 2012
OVALLE, F.: "Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus", FERTILITY AND STERILITY, 2002, pages 1095 - 1105
LEE, S. -H .: "Anti-diabetic effects of brown algae derived phlorotannins, marine polyphenols through diverse mechanisms", FITOTERAPIA, 2013, pages 129 - 136, XP028579860, DOI: doi:10.1016/j.fitote.2013.02.013
OVALLE, F.: "Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus", FERTILITY AND STERILITY, 2002, pages 1095 - 1105
LEE, S. -H .: "Anti-diabetic effects of brown algae derived phlorotannins, marine polyphenols through diverse mechanisms", FITOTERAPIA, 2013, pages 129 - 136, XP028579860, DOI: doi:10.1016/j.fitote.2013.02.013
Attorney, Agent or Firm:
CHOI, Kyu Whan (KR)
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