Title:
COMPOSITION FOR PREVENTING INFLAMMATIONS
Document Type and Number:
WIPO Patent Application WO/2012/033151
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a probiotics which can activate an aromatic hydrocarbon receptor (AhR) and can consequently prevent inflammatory damage in the digestive tract.
The present invention relates to: a probiotics capable of activating an AhR; an anti-inflammatory agent comprising the probiotics; an orally ingestible composition containing the anti-inflammatory agent; and a method for screening for the probiotics.
Inventors:
IKEGAMI SHUJI (JP)
MAKINO SEIYA (JP)
TOSHIMITSU TAKAYUKI (JP)
ITOH HIROYUKI (JP)
NAKAO ATSUHITO (JP)
MAKINO SEIYA (JP)
TOSHIMITSU TAKAYUKI (JP)
ITOH HIROYUKI (JP)
NAKAO ATSUHITO (JP)
Application Number:
PCT/JP2011/070436
Publication Date:
March 15, 2012
Filing Date:
September 08, 2011
Export Citation:
Assignee:
MEIJI CO LTD (JP)
IKEGAMI SHUJI (JP)
MAKINO SEIYA (JP)
TOSHIMITSU TAKAYUKI (JP)
ITOH HIROYUKI (JP)
NAKAO ATSUHITO (JP)
IKEGAMI SHUJI (JP)
MAKINO SEIYA (JP)
TOSHIMITSU TAKAYUKI (JP)
ITOH HIROYUKI (JP)
NAKAO ATSUHITO (JP)
International Classes:
C12N1/20; A23K1/16; A23L1/30; A61K31/192; A61K35/74; A61K35/741; A61K35/745; A61K35/747; A61P1/04; A61P29/00; C12N1/00; C12N15/09; C12Q1/02
Domestic Patent References:
| WO2005113767A1 | 2005-12-01 | |||
| WO2005113767A1 | 2005-12-01 | |||
| WO2007004361A1 | 2007-01-11 |
Other References:
HERIAS, M.V. ET AL.: "Probiotic effects of Lactobacillus casei on DSS-induced ulcerative colitis in mice.", INT. J. FOOD MICROBIOL., vol. 103, no. 2, 25 August 2005 (2005-08-25), pages 143 - 155, XP005002973
OSMAN, N. ET AL.: "Probiotics and Blueberry Attenuate the Severity of Dextran Sulfate Sodium (DSS)-Induced Colitis.", DIG. DIS. SCI., vol. 53, no. 9, 15 February 2008 (2008-02-15), pages 2464 - 2473, XP002501634
LEE, H-S. ET AL.: "Lactic acid bacteria inhibit Proinflammatory cytokine expression and bacterial glycosaminoglycan degradation activity in dextran sulfate sodium-induced colitic mice.", INT. IMMUNOPHARMACOL., vol. 8, no. 4, 5 February 2008 (2008-02-05), pages 574 - 580, XP022510890
KASAI, A. ET AL.: "DRESSA: biosensing of dioxin and dioxin-like chemicals using secreted alkaline phosphatase.", ANAL. BIOCHEM., vol. 335, no. 1, December 2004 (2004-12-01), pages 73 - 80, XP004616777
TAKAMURA, T. ET AL.: "Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice", IMMUNOL. CELL BIOL., vol. 88, 2010, pages 685 - 689
TAKAMURA, T. ET AL.: "Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis.", IMMUNOL. CELL BIOL., 15 February 2011 (2011-02-15), pages 1 - 6
STENSON, W.F., CURR OPIN GASTROENTEROL., vol. 23, no. 2, March 2007 (2007-03-01), pages 107 - 10
MARTEY, C.A. ET AL., AM J PHYSIOL LUNG CELL MOL PHYSIOL, vol. 289, 2005, pages L391 - L399
TAKAMURA, T. ET AL., IMMUNOLOGY AND CELL BIOLOGY, vol. 88, 2010, pages 685 - 689
KIMURA, A. ET AL., J EXP MED., vol. 206, no. 9, 31 August 2009 (2009-08-31), pages 2027 - 35
KASAI ET AL., TOXICOL APPL PHARMACOL., vol. 211, no. 1, 2006, pages 11 - 19
See also references of EP 2615163A4
OSMAN, N. ET AL.: "Probiotics and Blueberry Attenuate the Severity of Dextran Sulfate Sodium (DSS)-Induced Colitis.", DIG. DIS. SCI., vol. 53, no. 9, 15 February 2008 (2008-02-15), pages 2464 - 2473, XP002501634
LEE, H-S. ET AL.: "Lactic acid bacteria inhibit Proinflammatory cytokine expression and bacterial glycosaminoglycan degradation activity in dextran sulfate sodium-induced colitic mice.", INT. IMMUNOPHARMACOL., vol. 8, no. 4, 5 February 2008 (2008-02-05), pages 574 - 580, XP022510890
KASAI, A. ET AL.: "DRESSA: biosensing of dioxin and dioxin-like chemicals using secreted alkaline phosphatase.", ANAL. BIOCHEM., vol. 335, no. 1, December 2004 (2004-12-01), pages 73 - 80, XP004616777
TAKAMURA, T. ET AL.: "Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice", IMMUNOL. CELL BIOL., vol. 88, 2010, pages 685 - 689
TAKAMURA, T. ET AL.: "Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis.", IMMUNOL. CELL BIOL., 15 February 2011 (2011-02-15), pages 1 - 6
STENSON, W.F., CURR OPIN GASTROENTEROL., vol. 23, no. 2, March 2007 (2007-03-01), pages 107 - 10
MARTEY, C.A. ET AL., AM J PHYSIOL LUNG CELL MOL PHYSIOL, vol. 289, 2005, pages L391 - L399
TAKAMURA, T. ET AL., IMMUNOLOGY AND CELL BIOLOGY, vol. 88, 2010, pages 685 - 689
KIMURA, A. ET AL., J EXP MED., vol. 206, no. 9, 31 August 2009 (2009-08-31), pages 2027 - 35
KASAI ET AL., TOXICOL APPL PHARMACOL., vol. 211, no. 1, 2006, pages 11 - 19
See also references of EP 2615163A4
Attorney, Agent or Firm:
KUZUWA, Kiyoshi et al. (JP)
Seiji Kuzuwa (JP)
Seiji Kuzuwa (JP)
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