Title:
COMPOSITION FOR PREVENTING OR TREATING AMPK-RELATED DISEASES, COMPRISING GYNOSTEMMA LONGIPES VK1 EXTRACT OR COMPOUND ISOLATED THEREFROM AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2020/080641
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating AMPK-related diseases, comprising a Gynostemma longipes VK1 extract or a compound isolated therefrom as an active ingredient. It is found that the Gynostemma longipes VK1 extract or the compound isolated therefrom activate AMPK involved in various physiological activities such as glucose transport, fatty acid synthesis, and muscle regeneration, and promote proliferation of myoblasts as well as glucose uptake into adipocytes. Therefore, it is expected that the composition of the present invention can be used to develop a therapeutic agent or an animal drug, an ameliorating health functional food or animal feed for AMPK-related diseases such as muscle diseases, obesity, diabetes, and metabolic syndrome, having excellent effects.
Inventors:
OH WON KEUN (KR)
PHAM HA THANH TUNG (KR)
HUH JUNG MOO (KR)
TRAN VAN ON (VN)
NGHIEM DUC TRONG (VN)
PHAM HA THANH TUNG (KR)
HUH JUNG MOO (KR)
TRAN VAN ON (VN)
NGHIEM DUC TRONG (VN)
Application Number:
PCT/KR2019/008089
Publication Date:
April 23, 2020
Filing Date:
July 02, 2019
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
HANOI UNIV OF PHARMACY (VN)
HANOI UNIV OF PHARMACY (VN)
International Classes:
A61K36/42; A23K10/30; A23K20/163; A23L33/105; A23L33/125; A61K31/704; A61P3/00; A61P21/00
Domestic Patent References:
| WO2018090983A1 | 2018-05-24 |
Foreign References:
| KR101811048B1 | 2017-12-20 | |||
| KR100930580B1 | 2009-12-09 |
Other References:
ANH, P. T. ET AL.: "Damarane-type saponins from Gynostemma longipes and their cytotoxic activity", NATURAL PRODUCT COMMUNICATIONS, vol. 10, no. 8, 2015, pages 1351 - 1352, XP055704309
FANG, Z. P. ET AL.: "Structure of gypentonoside A from Gynostemma pentaphylum Makino", ACTA PHARMACEUTICA SINICA, vol. 31, no. 9, 1996, pages 680 - 683
PHAM, H. T. T. ET AL.: "Dammarane triterpenoids as AMP-activated protein kinase (AMPK) activators from Gynostemma longipes and their mechanism studies Asia Phatm", 3 July 2018 (2018-07-03)
PHAM, H. T. T. ET AL.: "Insulin mimetic activity of 3,4-seco and hexanordammarane triterpenoids isolated from Gynostemma longipes", THE 10TH ANRRC INTERNATIONAL MEETING, vol. 81, no. 11, 5 September 2018 (2018-09-05), pages 2470 - 2482, XP055704426, DOI: 10.1021/acs.jnatprod.8b00524
PHAM, H. T. T. ET AL.: "Insulin mimetic activity of 3,4-seco and hexanordammarane triterpenoids isolated from Gynostemma longipes", JOURNAL OF NATURAL PRODUCTS, vol. 81, 2 November 2018 (2018-11-02), pages 2470 - 2482, XP055704426
HA, T. K. Q. ET AL.: "12,2.3-Dione dammarane triterpenes from Gynostemma longipes and their muscle cell proliferation activities via activation of the AMPK pathway", SCIENTIFIC REPORTS, vol. 9, no. 1186, 4 February 2019 (2019-02-04), pages 1 - 15, XP055704428, DOI: 10.1038/s41598-018-37808-9
FANG, Z. P. ET AL.: "Structure of gypentonoside A from Gynostemma pentaphylum Makino", ACTA PHARMACEUTICA SINICA, vol. 31, no. 9, 1996, pages 680 - 683
PHAM, H. T. T. ET AL.: "Dammarane triterpenoids as AMP-activated protein kinase (AMPK) activators from Gynostemma longipes and their mechanism studies Asia Phatm", 3 July 2018 (2018-07-03)
PHAM, H. T. T. ET AL.: "Insulin mimetic activity of 3,4-seco and hexanordammarane triterpenoids isolated from Gynostemma longipes", THE 10TH ANRRC INTERNATIONAL MEETING, vol. 81, no. 11, 5 September 2018 (2018-09-05), pages 2470 - 2482, XP055704426, DOI: 10.1021/acs.jnatprod.8b00524
PHAM, H. T. T. ET AL.: "Insulin mimetic activity of 3,4-seco and hexanordammarane triterpenoids isolated from Gynostemma longipes", JOURNAL OF NATURAL PRODUCTS, vol. 81, 2 November 2018 (2018-11-02), pages 2470 - 2482, XP055704426
HA, T. K. Q. ET AL.: "12,2.3-Dione dammarane triterpenes from Gynostemma longipes and their muscle cell proliferation activities via activation of the AMPK pathway", SCIENTIFIC REPORTS, vol. 9, no. 1186, 4 February 2019 (2019-02-04), pages 1 - 15, XP055704428, DOI: 10.1038/s41598-018-37808-9
Attorney, Agent or Firm:
GHONG-GAN INTERNATIONAL PATENT LAW FIRM (KR)
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