Title:
COMPOSITION FOR PREVENTING AND TREATING AMYLOID DISEASES, COMPRISING CYCLOPHILIN B
Document Type and Number:
WIPO Patent Application WO/2012/039578
Kind Code:
A3
Abstract:
The present invention relates to a composition for preventing and treating amyloid diseases, comprising a cyclophilin B (CypB) protein or a nucleic acid having a nucleotide sequence encoding the protein, to a method for treating amyloid diseases including a step of administering the composition to a subject requiring treatment of amyloid diseases, and to a method for screening drugs for preventing or treating amyloid diseases. According to the present invention, the composition comprising of cyclophilin B for preventing or treating amyloid diseases may effectively treat amyloid diseases which are caused by the neurotoxic effects of neuritic plaques formed from the deposition of the amyloid-β peptide and other materials. Examples of amyloid diseases may include age-related cognitive decline, mild cognitive impairment (MCI), vascular dementia, cerebral amyloid angiopathy (CAA), hereditary intracerebral hemorrhage, senile dementia, Down's syndrome, inclusion body myositis (IBM), age-related macular degeneration (ARMD), chronic inflammation, multiple myeloma, type II diabetes, Creutzfeldt-Jakob disease, and Alzheimer's disease.
Inventors:
CHOE WON CHAE (KR)
OH YOO JUNG (KR)
OH YOO JUNG (KR)
Application Number:
PCT/KR2011/006942
Publication Date:
June 28, 2012
Filing Date:
September 20, 2011
Export Citation:
Assignee:
UNIV KYUNG HEE UNIV IND COOP GROUP (KR)
CHOE WON CHAE (KR)
OH YOO JUNG (KR)
CHOE WON CHAE (KR)
OH YOO JUNG (KR)
International Classes:
A61K38/16; A61K38/17; A61P25/00; A61P25/28
Foreign References:
| US20070032423A1 | 2007-02-08 | |||
| KR20100111475A | 2010-10-15 |
Other References:
JIN HWAN KIM ET AL.: "Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress", J CELL SCI., vol. 121, 2008, pages 3636 - 3648
DATABASE PROTEIN 1 June 2010 (2010-06-01), accession no. P_001106590
DATABASE PROTEIN 1 June 2010 (2010-06-01), accession no. P_001106590
Attorney, Agent or Firm:
SON, Min (6th Floor City Air Tower,159-9, Samseong-dong, Gangnam-gu, Seoul 135-973, KR)
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Claims: