Title:
COMPOSITION FOR PREVENTING AND TREATING ANXIETY DISORDER, CONTAINING CHOLINERGIC ENHANCER
Document Type and Number:
WIPO Patent Application WO/2010/128696
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing and treating anxiety disorder, containing a cholinergic enhancer, and more specifically, a cholinergic enhancer restores the increased anxiety and the cholinergic theta rhythm reduced by the deletion of C (phospholipase C, PLC)-β4 back to normal levels, thereby enabling the effective treatment of an anxiety disorder patient through control of cholinergic theta rhythm profile. Therefore, said cholinergic enhancer can be usefully used for preventing and treating anxiety disorder.
Inventors:
SHIN HEE-SUP (KR)
SHIN JONGHAN (KR)
GANGADHARAN GIREESH (KR)
KIM SEONG-WOOK (KR)
KIM DUK-SOO (KR)
LEE SUKYUNG (KR)
KIM YEON-SOO (KR)
SHIN JONGHAN (KR)
GANGADHARAN GIREESH (KR)
KIM SEONG-WOOK (KR)
KIM DUK-SOO (KR)
LEE SUKYUNG (KR)
KIM YEON-SOO (KR)
Application Number:
PCT/KR2009/002366
Publication Date:
November 11, 2010
Filing Date:
May 06, 2009
Export Citation:
Assignee:
KOREA INST SCI & TECH (KR)
SHIN HEE-SUP (KR)
SHIN JONGHAN (KR)
GANGADHARAN GIREESH (KR)
KIM SEONG-WOOK (KR)
KIM DUK-SOO (KR)
LEE SUKYUNG (KR)
KIM YEON-SOO (KR)
SHIN HEE-SUP (KR)
SHIN JONGHAN (KR)
GANGADHARAN GIREESH (KR)
KIM SEONG-WOOK (KR)
KIM DUK-SOO (KR)
LEE SUKYUNG (KR)
KIM YEON-SOO (KR)
International Classes:
A61K31/27; A61P25/22; G01N27/26; G01N33/15
Other References:
EDUARDO BRUERA ET AL.: "The effect of donepezil on sedation and other symptoms in patients receiving opioids for cancer pain: A pilot study", JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, vol. 26, no. 5, 5 November 2003 (2003-11-05), pages 1049 - 1054, XP055138949, DOI: doi:10.1016/S0885-3924(03)00332-4
DEBBY VAN DAM ET AL.: "Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model", PSYCHOPHARMACOLOGY, vol. 180, 2005, pages 177 - 190, XP019326451, DOI: doi:10.1007/s00213-004-2132-z
KAASINEN, VALTTERI ET AL.: "Regional effects of donepezil and rivastigmine on cortical acetylcholinesterase activity in alzheimer's disease", JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, vol. 22, no. 6, December 2002 (2002-12-01), pages 615 - 620
CHRISTINA WOLFSON ET AL.: "Donepezil and rivastigmine in the treatment of alzheimer's disease: a best-evidence synthesis of the published data on their efficacy and cost-effectivness", CLINICAL THERAPEUTICS, vol. 24, no. 6, 2002, pages 862 - 886
DEBBY VAN DAM ET AL.: "Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model", PSYCHOPHARMACOLOGY, vol. 180, 2005, pages 177 - 190, XP019326451, DOI: doi:10.1007/s00213-004-2132-z
KAASINEN, VALTTERI ET AL.: "Regional effects of donepezil and rivastigmine on cortical acetylcholinesterase activity in alzheimer's disease", JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, vol. 22, no. 6, December 2002 (2002-12-01), pages 615 - 620
CHRISTINA WOLFSON ET AL.: "Donepezil and rivastigmine in the treatment of alzheimer's disease: a best-evidence synthesis of the published data on their efficacy and cost-effectivness", CLINICAL THERAPEUTICS, vol. 24, no. 6, 2002, pages 862 - 886
Attorney, Agent or Firm:
LEE, WON-HEE (KR)
이원희 (KR)
이원희 (KR)
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