Title:
COMPOSITION FOR PREVENTING OR TREATING BRAIN TUMOR COMPRISING COMBINATION OF POORLY DIFFERENTIATED COMPOUNDS AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2022/158850
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating cancer, specifically a brain tumor, and more specifically glioblastoma. The present invention exhibits a remarkable inhibitory effect on cancer cell proliferation through co-administration of a pyrazolyl benzamide derivative compound and a cAMP activator even at a low dose at which no significant anticancer activity would be measured when administered alone. Accordingly, the composition of the present invention may be used as an effective anticancer composition capable of long-term, low-dose administration without tolerance or side effects. The present invention directly converts malignant glioblastoma into benign nerve cells to simultaneously achieve removal of a tumor and quantitative restoration of lost cells, such that the present invention may also be used as a disease-modifying drug composition that reversibly recovers nervous tissue damaged by a tumor, by moving away from conventional symptomatic treatment.
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Inventors:
HA YOON (KR)
OH JINSOO (KR)
OH JINSOO (KR)
Application Number:
PCT/KR2022/000982
Publication Date:
July 28, 2022
Filing Date:
January 19, 2022
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
International Classes:
A61K31/454; A23L33/10; A61K31/215; A61P35/00; C12N5/0793
Domestic Patent References:
| WO2019241620A1 | 2019-12-19 |
Foreign References:
| KR20170080390A | 2017-07-10 | |||
| US20080161251A1 | 2008-07-03 |
Other References:
SQUIRES MATTHEW S., FELTELL RUTH E., WALLIS NICOLA G., LEWIS E. JONATHAN, SMITH DONNA-MICHELLE, CROSS DAVID M., LYONS JOHN F., THO: "Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 8, no. 2, 1 February 2009 (2009-02-01), US , pages 324 - 332, XP055952905, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-08-0890
SANTO L; VALLET S; HIDESHIMA T; CIRSTEA D; IKEDA H; POZZI S; PATEL K; OKAWA Y; GORGUN G; PERRONE G; CALABRESE E; YULE M; SQUIRES M: "AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3β activation and RNA polymerase II inhibition", ONCOGENE, NATURE PUBLISHING GROUP UK, LONDON, vol. 29, no. 16, 25 January 2010 (2010-01-25), London , pages 2325 - 2336, XP037744329, ISSN: 0950-9232, DOI: 10.1038/onc.2009.510
SANTO L; VALLET S; HIDESHIMA T; CIRSTEA D; IKEDA H; POZZI S; PATEL K; OKAWA Y; GORGUN G; PERRONE G; CALABRESE E; YULE M; SQUIRES M: "AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3β activation and RNA polymerase II inhibition", ONCOGENE, NATURE PUBLISHING GROUP UK, LONDON, vol. 29, no. 16, 25 January 2010 (2010-01-25), London , pages 2325 - 2336, XP037744329, ISSN: 0950-9232, DOI: 10.1038/onc.2009.510
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
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