Title:
COMPOSITION FOR PREVENTING OR TREATING DIABETES BY USING CD9, AND METHOD FOR SCREENING FOR ANTIDIABETIC AGENTS
Document Type and Number:
WIPO Patent Application WO/2020/017788
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating diabetes by using CD9, and a method for screening for antidiabetic agents. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating diabetes, containing, as an active ingredient, a CD9 protein expression or activity inhibitor or an insulin-secreting cell from which a CD9 gene is deleted, and to a method for screening for antidiabetic agents, comprising the steps of: (a) bringing a test substance in contact with cells in which a CD9 gene is expressed; (b) measuring, in control group cells in which the cells do not make contact with the test substance, the expression level of the CD9 gene; and (c) selecting, as a candidate agent for treating diabetes, the test substance which causes the CD9 gene expression level to be lower than that of the control group cells.
Inventors:
HWANG IN HU (KR)
Application Number:
PCT/KR2019/008037
Publication Date:
January 23, 2020
Filing Date:
July 02, 2019
Export Citation:
Assignee:
HWANG IN HU (KR)
International Classes:
A61K48/00; A61K39/395; A61P3/10; C12Q1/6883
Domestic Patent References:
| WO2005054512A2 | 2005-06-16 |
Foreign References:
| KR20180034830A | 2018-04-05 | |||
| KR101974202B1 | 2019-04-30 |
Other References:
MARCELIN, G.: "A PDGFRa-Mediated Switch toward CD 9high Adipocyte Progenitors Controls Obesity-Induced Adipose Tissue Fibrosis", CELL METABOLISM, vol. 25, no. 3, 7 March 2017 (2017-03-07), pages 673 - 685, XP055678267
GARCIA-CONTRERAS, M.: "Exosomes as biomarkers and therapeutic tools for type 1 diabetes mellitus", EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCE, vol. 21, no. 12, 2017, pages 2940 - 2956, XP055678270
GARCIA-CONTRERAS, M.: "Exosomes as biomarkers and therapeutic tools for type 1 diabetes mellitus", EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCE, vol. 21, no. 12, 2017, pages 2940 - 2956, XP055678270
Attorney, Agent or Firm:
LEE, Hee Sook (KR)
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