Title:
COMPOSITION FOR PREVENTING OR TREATING EYE DISEASES COMPRISING EXTRACELLULAR VESICLES DERIVED FROM LACTOBACILLUS PARACASEI
Document Type and Number:
WIPO Patent Application WO/2022/255553
Kind Code:
A1
Abstract:
The present invention relates to extracellular vesicles derived from Lactobacillus paracasei and use thereof and, more specifically, to a composition for ameliorating, preventing and treating eye diseases, comprising, as an active ingredient, Lactobacillus paracasei-derived vesicles that can effectively suppress the occurrence of eye diseases, which occur in relation to cellular senescence caused by oxidative stress.
Inventors:
KIM YOON-KEUN (KR)
Application Number:
PCT/KR2021/013717
Publication Date:
December 08, 2022
Filing Date:
October 06, 2021
Export Citation:
Assignee:
MD HEALTHCARE INC (KR)
International Classes:
A61K35/747; A23L33/135; A61K8/99; A61K9/00; A61P3/00; A61P37/00; A61Q19/00
Foreign References:
| KR20200053531A | 2020-05-18 | |||
| EP3646851A2 | 2020-05-06 | |||
| KR102257130B1 | 2021-05-28 | |||
| KR20210072078A | 2021-06-16 | |||
| KR20210130843A | 2021-11-01 |
Other References:
MORITA, YUJI ET AL.: "Lactobacillus paracasei KW3110 Prevents Blue Light-Induced Inflammation and Degeneration in the Retina", NUTRIENTS, vol. 10, no. 1991, 2018, pages 1 - 12, XP055975288, DOI: 10.3390/nu10121991
LEE, JAE WOO K: "Research Trend of Extracellular Vesicles (Exosomes", BRIC VIEW, 4 February 2020 (2020-02-04), pages 1 - 11, XP055972910, Retrieved from the Internet
MORITA YUJI, MIWA YUKIHIRO, JOUNAI KENTA, FUJIWARA DAISUKE, KURIHARA TOSHIHIDE, KANAUCHI OSAMU: "Lactobacillus paracasei KW3110 Prevents Blue Light-Induced Inflammation and Degeneration in the Retina", NUTRIENTS, vol. 10, no. 12, 1 January 2018 (2018-01-01), pages 1 - 12, XP055975288, DOI: 10.3390/nu10121991
CHOI, JI HYUN ET AL.: "Lactobacillus paracasei-derived extracellular vesicles attenuate the intestinal inflammatory response by augmenting the endoplasmic reticulum stress pathway", EXPERIMENTAL & MOLECULAR MEDICIN E, vol. 52, 2020, pages 423 - 437, XP055832897, DOI: 10.1038/s12276-019-0359-3
BEATTY S.KOH H.PHIL M.HENSON D.BOULTON M.: "he role of oxidative stress in the pathogenesis of age-related macular degeneration", SURV. OPHTHALMOL., vol. 45, no. 2, 2000, pages 115 - 134, XP055020899, DOI: 10.1016/S0039-6257(00)00140-5
See also references of EP 4119151A4
LEE, JAE WOO K: "Research Trend of Extracellular Vesicles (Exosomes", BRIC VIEW, 4 February 2020 (2020-02-04), pages 1 - 11, XP055972910, Retrieved from the Internet
MORITA YUJI, MIWA YUKIHIRO, JOUNAI KENTA, FUJIWARA DAISUKE, KURIHARA TOSHIHIDE, KANAUCHI OSAMU: "Lactobacillus paracasei KW3110 Prevents Blue Light-Induced Inflammation and Degeneration in the Retina", NUTRIENTS, vol. 10, no. 12, 1 January 2018 (2018-01-01), pages 1 - 12, XP055975288, DOI: 10.3390/nu10121991
CHOI, JI HYUN ET AL.: "Lactobacillus paracasei-derived extracellular vesicles attenuate the intestinal inflammatory response by augmenting the endoplasmic reticulum stress pathway", EXPERIMENTAL & MOLECULAR MEDICIN E, vol. 52, 2020, pages 423 - 437, XP055832897, DOI: 10.1038/s12276-019-0359-3
BEATTY S.KOH H.PHIL M.HENSON D.BOULTON M.: "he role of oxidative stress in the pathogenesis of age-related macular degeneration", SURV. OPHTHALMOL., vol. 45, no. 2, 2000, pages 115 - 134, XP055020899, DOI: 10.1016/S0039-6257(00)00140-5
See also references of EP 4119151A4
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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