Title:
COMPOSITION FOR PREVENTING OR TREATING FRACTURE OR OSTEOPOROSIS USING SLIT-ROBO SYSTEM
Document Type and Number:
WIPO Patent Application WO/2013/187730
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating fracture or osteoporosis, comprising, as an active ingredient, a gene selected from a group consisting of slit1, slit2, slit3, robo1, robo2 and vilse, or an expressed protein of the gene. The present invention also relates to a marker composition for predicting the risk of fracture or osteoporosis, which comprises the protein, to a kit for predicting the risk of fracture or osteoporosis, which comprises an antibody that specifically binds to the protein, and to an information provision method for predicting the risk of fracture or osteoporosis, comprising a step of measuring the level of expression of the slit protein by means of an antigen-antibody binding reaction using an antibody that specifically binds to the protein. The slit 3 of the present invention may increase bone formation and decrease bone reabsorption in a cell and animal model, and has a negative correlation with the incidence rate of osteoporosis, and therefore, can be used effectively as a composition for preventing or treating fracture or osteoporosis and as a bio marker for prediction of the risk of fracture or osteoporosis.
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Inventors:
KOH JUNG-MIN (KR)
KIM GHI SU (KR)
LEE SEUNG HUN (KR)
LEE YOUNG-SUN (KR)
KIM BEOM-JUN (KR)
KIM GHI SU (KR)
LEE SEUNG HUN (KR)
LEE YOUNG-SUN (KR)
KIM BEOM-JUN (KR)
Application Number:
PCT/KR2013/005282
Publication Date:
December 19, 2013
Filing Date:
June 14, 2013
Export Citation:
Assignee:
ASAN FOUNDATION (KR)
International Classes:
A61K39/395; A61K38/18; A61P19/00; A61P19/10
Foreign References:
| US5371015A | 1994-12-06 |
Other References:
SUN ET AL.: "Regulation of osteoblast differentiation by slit2 in osteoblastic cells", CELLS TISSUES ORGANS, vol. 190, no. 2, 2009, pages 69 - 80, XP009145715
PEACOCK, M. ET AL., ENDOCR. REV, vol. 23, 2002, pages 303 - 326
AKHTER, M.P ET AL., BONE, vol. 41, no. 1, 2007, pages 111 - 6
FOGARTY, P. ET AL., MATURITAS, vol. 52, no. 1, 2005, pages 3 - 6
PALACIOS, S. ET AL., MATURITAS, vol. 52, no. 1, 15 December 2004 (2004-12-15), pages 53 - 60
H. NEURATH; R. L. HILL: "The Proteins", 1979, ACADEMIC PRESS
MERRIFLELD, J. AMER. CHEM. SOC., vol. 85, 1963, pages 2149 - 2156
SAMBROOK ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOUR LABORATORY PRESS
"Remington's Pharmaceutical Science", MACK PUBLISHING COMPANY
KOHLER; MILSTEIN, EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 6, 1976, pages 511 - 519
CLACKSON ET AL., NATURE, vol. 352, 1991, pages 624 - 628
MARKS ET AL., J. MOL. BIOL., vol. 222, no. 58, 1991, pages 1 - 597
DICKINSON RE ET AL., REPRODUCTION, vol. 139, 2010, pages 697 - 704
See also references of EP 2862580A4
PEACOCK, M. ET AL., ENDOCR. REV, vol. 23, 2002, pages 303 - 326
AKHTER, M.P ET AL., BONE, vol. 41, no. 1, 2007, pages 111 - 6
FOGARTY, P. ET AL., MATURITAS, vol. 52, no. 1, 2005, pages 3 - 6
PALACIOS, S. ET AL., MATURITAS, vol. 52, no. 1, 15 December 2004 (2004-12-15), pages 53 - 60
H. NEURATH; R. L. HILL: "The Proteins", 1979, ACADEMIC PRESS
MERRIFLELD, J. AMER. CHEM. SOC., vol. 85, 1963, pages 2149 - 2156
SAMBROOK ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOUR LABORATORY PRESS
"Remington's Pharmaceutical Science", MACK PUBLISHING COMPANY
KOHLER; MILSTEIN, EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 6, 1976, pages 511 - 519
CLACKSON ET AL., NATURE, vol. 352, 1991, pages 624 - 628
MARKS ET AL., J. MOL. BIOL., vol. 222, no. 58, 1991, pages 1 - 597
DICKINSON RE ET AL., REPRODUCTION, vol. 139, 2010, pages 697 - 704
See also references of EP 2862580A4
Attorney, Agent or Firm:
HWANG MOK PARK IP GROUP et al. (KR)
특허법인 충정 (KR)
특허법인 충정 (KR)
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