Title:
COMPOSITION FOR PREVENTING OR TREATING IMPOTENCE, ISCHEMIC DISEASES OR PERIPHERAL NERVE DISEASES, CONTAINING FUSION PROTEIN COMPRISING LRG1 GLYCOPROTEIN
Document Type and Number:
WIPO Patent Application WO/2018/021778
Kind Code:
A1
Abstract:
The present invention relates to a fusion protein comprising an LRG1 glycoprotein and a composition for preventing or treating impotence, ischemic diseases or peripheral nerve diseases, containing the same as an active ingredient. The LRG1 glycoprotein or an LRG1-Fc fusion protein according to the present invention increases the level of endothelial cell-specific and nerve cell-specific proteins, and thus has an excellent effect of improving impotence such as inducing the regeneration of the endothelial cells and nerve cells of the corpus cavernosum and increasing penile erection, thereby being usefully used for the prevention or treatment of impotence. Further, the LRG1 glycoprotein or LRG1-Fc fusion protein according to the present invention has the effect of regenerating blood vessels and nerves, and thus can be usefully used for the prevention or treatment of ischemic diseases or peripheral nerve diseases.
Inventors:
SUH JUN KYU (KR)
RYU JI KAN (KR)
KIM HO MIN (KR)
YIN GUO NAN (KR)
KANG JI IN (KR)
RYU JI KAN (KR)
KIM HO MIN (KR)
YIN GUO NAN (KR)
KANG JI IN (KR)
Application Number:
PCT/KR2017/007949
Publication Date:
February 01, 2018
Filing Date:
July 24, 2017
Export Citation:
Assignee:
INHA-INDUSTRY PARTNERSHIP INST (KR)
KOREA ADVANCED INST SCI & TECH (KR)
KOREA ADVANCED INST SCI & TECH (KR)
International Classes:
C07K14/47; A23L33/18; A61K38/17; A61K47/50
Foreign References:
| US20160184458A1 | 2016-06-30 | |||
| US8790647B2 | 2014-07-29 |
Other References:
PEK, SHARON L. T.: "Elevation of a novel angiogenic factor, leucine-rich - a2-glycoprotein (LRG1), is associated with arterial stiffness, endothelial dysfunction, and peripheral arterial disease in patients with type 2 diabetes", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, XP055603370
WANG, XIAOMENG: "LRG1 promotes angiogenesis by modulating endothelial TGF-B signalling", NATURE, vol. 499, 18 July 2013 (2013-07-18), pages 306 - 311, XP055277931, DOI: doi:10.1038/nature12345
HUNG, PEIR-HAUR: "Plasma proteomic analysis of the critical limb ischemia markers in diabetic patients with hemodialysis", MOLECULAR BIOSYSTEMS, vol. 7, 2011, pages 1990 - 1998, XP009172564
WANG, XIAOMENG: "LRG1 promotes angiogenesis by modulating endothelial TGF-B signalling", NATURE, vol. 499, 18 July 2013 (2013-07-18), pages 306 - 311, XP055277931, DOI: doi:10.1038/nature12345
HUNG, PEIR-HAUR: "Plasma proteomic analysis of the critical limb ischemia markers in diabetic patients with hemodialysis", MOLECULAR BIOSYSTEMS, vol. 7, 2011, pages 1990 - 1998, XP009172564
Attorney, Agent or Firm:
KIM, Soon Woong (KR)
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