Title:
COMPOSITION FOR PREVENTING OR TREATING LIVER FIBROSIS, CONTAINING EXOSOME OR EXOSOME-DERIVED RIBONUCLEIC ACID
Document Type and Number:
WIPO Patent Application WO/2019/050071
Kind Code:
A1
Abstract:
The present invention relates to a composition or a cell therapeutic agent for preventing or treating liver fibrosis, containing an exosome or exosome-derived ribonucleic acid. The exosome or ribonucleic acid derived therefrom, of the present invention, has effects of inhibiting activities of hepatic stellate cells and Kupffer cells and reducing the expression of α-SMA and inhibits the progression of liver fibrosis by inhibiting the deposition of collagen, thereby being effectively usable as a cell therapeutic agent for the prevention or treatment of liver fibrosis.
Inventors:
HONG JAE SANG (KR)
LEE DO HOON (KR)
JANG YU JIN (KR)
KIM JONG HOON (KR)
LEE YOUNG SIK (KR)
LEE DO HOON (KR)
JANG YU JIN (KR)
KIM JONG HOON (KR)
LEE YOUNG SIK (KR)
Application Number:
PCT/KR2017/009910
Publication Date:
March 14, 2019
Filing Date:
September 08, 2017
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
A61K35/28; A23L33/10; A23L33/13; A61K35/407; A61K48/00
Domestic Patent References:
| WO2016054094A1 | 2016-04-07 | |||
| WO2017058938A1 | 2017-04-06 |
Foreign References:
| KR20170103697A | 2017-09-13 |
Other References:
HONG, J.: "Exosomes derived from mesenchymal stem cells and differentiated hepatocyte-like cells relieve liver fibrosis", INTERNATIONAL CONFERENCE OF THE KOREAN SOCIETY FOR MOLECULAR AND CELLULAR BIOLOGY, 21 September 2015 (2015-09-21), Seoul Korea
MURAKAMI ET AL.: "The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families", PLOS ONE, January 2011 (2011-01-01)
MURAKAMI ET AL.: "The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families", PLOS ONE, January 2011 (2011-01-01)
Attorney, Agent or Firm:
KIM, Soon Woong (KR)
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