Title:
COMPOSITION FOR PREVENTING OR TREATING NEURODEGENERATIVE DISEASES, CONTAINING DITERPENE-BASED COMPOUND
Document Type and Number:
WIPO Patent Application WO/2019/098699
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases, containing a diterpene-based compound or a pharmaceutically acceptable salt thereof. Specifically, a diterpene-based compound of the present invention activates a Nurr1 protein and inhibits an inflammatory response, thereby enabling the prevention or treatment of neurodegenerative diseases caused by the inhibition of Nurr1 protein activity.
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Inventors:
KIM WON GON (KR)
HAN BAEK SOO (KR)
BYUN JEONG SU (KR)
NGUYEN VAN MINH (KR)
CHOI HA YOUNG (KR)
HAN BAEK SOO (KR)
BYUN JEONG SU (KR)
NGUYEN VAN MINH (KR)
CHOI HA YOUNG (KR)
Application Number:
PCT/KR2018/013990
Publication Date:
May 23, 2019
Filing Date:
November 15, 2018
Export Citation:
Assignee:
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
International Classes:
A61K31/357; A23L33/10; A61K31/215; A61K31/216
Domestic Patent References:
| WO2012138034A1 | 2012-10-11 | |||
| WO2018089561A1 | 2018-05-17 | |||
| WO2010004221A2 | 2010-01-14 |
Foreign References:
| KR20140117564A | 2014-10-07 | |||
| EP0457295A2 | 1991-11-21 | |||
| US20090226401A1 | 2009-09-10 |
Other References:
JACOBSEN, J. S. ET AL.: "The Release of Alzheimer's Disease beta Amyloid Peptide Is Reduced by Phorbol Treatment", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 11, 1994, pages 8376 - 8382, XP055611898
HAN, B.-S. ET AL.: "Daphnane Diterpenes from Daphne Genkwa Activate Nurrl and Have a Neuroprotective Effect in an Animal Model of Parkinson's Disease", JOURNAL OF NATURAL PRODUCT, vol. 79, no. 6, 2016, pages 1604 - 1609, XP055486196, DOI: 10.1021/acs.jnatprod.6b00110
LIU, F. ET AL.: "Nitric Oxide Inhibitory Daphnane Diterpenoids as Potential Antitieuroitiflammatory Agents for AD from the Twigs of Trigonostemon Thyrsoideus", BIOORGANIC CHEMISTRY, vol. 75, 7 September 2017 (2017-09-07), pages 149 - 156, XP085278615
HAN, B.-S. ET AL.: "Daphnane and Phorbol Diterpenes, Anti-neuroinnammatory Compounds with Nurr1 Activation from the Roots and Stems of Daphne Genkwa", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, vol. 40, no. 12, 1 December 2017 (2017-12-01), pages 2205 - 2211, XP055611899
SARKAR S ET AL., NEUROTOXICOLOGY, vol. 44, 2014, pages 250 - 262
BOWER JH ET AL., NEUROLOGY, vol. 67, 2006, pages 494 - 496
See also references of EP 3701946A4
HAN, B.-S. ET AL.: "Daphnane Diterpenes from Daphne Genkwa Activate Nurrl and Have a Neuroprotective Effect in an Animal Model of Parkinson's Disease", JOURNAL OF NATURAL PRODUCT, vol. 79, no. 6, 2016, pages 1604 - 1609, XP055486196, DOI: 10.1021/acs.jnatprod.6b00110
LIU, F. ET AL.: "Nitric Oxide Inhibitory Daphnane Diterpenoids as Potential Antitieuroitiflammatory Agents for AD from the Twigs of Trigonostemon Thyrsoideus", BIOORGANIC CHEMISTRY, vol. 75, 7 September 2017 (2017-09-07), pages 149 - 156, XP085278615
HAN, B.-S. ET AL.: "Daphnane and Phorbol Diterpenes, Anti-neuroinnammatory Compounds with Nurr1 Activation from the Roots and Stems of Daphne Genkwa", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, vol. 40, no. 12, 1 December 2017 (2017-12-01), pages 2205 - 2211, XP055611899
SARKAR S ET AL., NEUROTOXICOLOGY, vol. 44, 2014, pages 250 - 262
BOWER JH ET AL., NEUROLOGY, vol. 67, 2006, pages 494 - 496
See also references of EP 3701946A4
Attorney, Agent or Firm:
B&IP-JOOWON PATENT AND LAW FIRM (KR)
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