Title:
COMPOSITION FOR PREVENTING OR TREATING NEUROINFLAMMATORY DISORDERS, COMPRISING BEE VENOM EXTRACT AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2020/197332
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating neuroinflammatory disorders, comprising a bee venom extract as an active ingredient. More specifically, the present invention provides a pharmaceutical composition or a health functional food composition for preventing or treating neuroinflammatory disorders, both of which comprise, as an active ingredient, a bee venom extract in which the amount of phospholipase A2 (PLA2) is 50 to 85%. The bee venom extract alleviates decreased motor functions caused by neurotoxicity and has neuroprotective and neuroinflammation-relieving effects, thereby enabling the prevention or treatment of neuroinflammatory disorders. Particularly, a pharmaceutical composition according to the present invention can further improve an effect of preventing or treating neuroinflammatory disorders by being subcutaneously administered or by being co-administered with a STAT3 inhibitor or an NF-κB inhibitor, thereby enabling more effective prevention or treatment of neuroinflammatory disorders.
Inventors:
KIM KUK HYUN (KR)
RHEE HAE IN (KR)
KIM SEHYUN (KR)
RHEE HAE IN (KR)
KIM SEHYUN (KR)
Application Number:
PCT/KR2020/004239
Publication Date:
October 01, 2020
Filing Date:
March 27, 2020
Export Citation:
Assignee:
INIST ST CO LTD (KR)
International Classes:
A61K35/64; A23L33/10; A61K38/46; A61P25/28
Domestic Patent References:
| WO2010000089A1 | 2010-01-07 |
Foreign References:
| KR20130098110A | 2013-09-04 | |||
| KR20140120508A | 2014-10-14 | |||
| KR20120139313A | 2012-12-27 | |||
| KR20110080383A | 2011-07-13 |
Other References:
BAEK, H.: "Bee venom phospholipase A2 ameliorates Alzheimer' s disease pathology in A beta vaccination treatment without inducing neuro-inflammation in a 3xTg-AD mouse model", SCIENTIFIC REPORTS, vol. 8, no. 1, 2018, pages 17369, XP055743616, DOI: 10.1038/s41598-018-35030-1
HAM, H. J.: "Bee venom soluble phospholipase A2 exerts neuroprotective ef fects in a lipopolysaccharide-induced mouse model of Alzheimer's disease vi a inhibition of nuclear factor-kappa B", FRONTIERS IN AGING NEUROSCIENCE, vol. 11, 1 November 2019 (2019-11-01), pages 1 - 14, XP055743619, DOI: 10.3389/fnagi.2019.00287
See also references of EP 3949974A4
HAM, H. J.: "Bee venom soluble phospholipase A2 exerts neuroprotective ef fects in a lipopolysaccharide-induced mouse model of Alzheimer's disease vi a inhibition of nuclear factor-kappa B", FRONTIERS IN AGING NEUROSCIENCE, vol. 11, 1 November 2019 (2019-11-01), pages 1 - 14, XP055743619, DOI: 10.3389/fnagi.2019.00287
See also references of EP 3949974A4
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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