Title:
COMPOSITION FOR PREVENTING OR TREATING NEUROPSYCHOLOGICAL DISEASES COMPRISING AUCUBIN
Document Type and Number:
WIPO Patent Application WO/2019/098674
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating neuropsychological diseases comprising aucubin and, particularly, to a pharmaceutical composition for preventing or treating mental diseases, a food composition, a method for treating mental diseases, and a composition for maintaining survival, promoting regeneration, or preventing the death of GABA neurons, comprising aucubin or a pharmaceutically acceptable salt thereof as an active ingredient. The aucubin according to the present invention exhibits the effect of maintaining the survival, promoting the regeneration, and preventing the death of GABA neurons and promoting the production of GABA which is a neurotransmitter, and can be usefully used in the treatment or prevention of mental diseases, such as ADHD, autism, or etc. caused by a deficiency of GABA neurons.
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Inventors:
KIM YUNHEE (KR)
Application Number:
PCT/KR2018/013903
Publication Date:
May 23, 2019
Filing Date:
November 14, 2018
Export Citation:
Assignee:
UNIV INDUSTRY COOPERATION GROUP KYUNG HEE UNIV (KR)
International Classes:
A61K31/7048; A23L33/10; A23L33/125
Foreign References:
| KR20150123152A | 2015-11-03 | |||
| CN105596357A | 2016-05-25 | |||
| KR101912544B1 | 2018-10-26 |
Other References:
KIM, Y. M.: "Aucubin promotes neurite outgrowth in neural stem cells and axonal regeneration in sciatic nerves", EXPERIMENTAL NEUROBIOLOGY, September 2014 (2014-09-01), pages 238 - 245, XP55611215
KANG, Z.: "Research advances in pharmacology of aucubin and aucubigenin", ZHONGGUO ZHONG YAO ZA ZHI, vol. 32, no. 24, 2007, pages 2585 - 2587
EGHORN, L. F. ET AL.: "Positive allosteric modulation of the GHB high-affinity binding site by the GABAA receptor modulator monastrol and the flavonoid catechin", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 740, 2014, pages 570 - 577, XP55611221
KANG, Z.: "Research advances in pharmacology of aucubin and aucubigenin", ZHONGGUO ZHONG YAO ZA ZHI, vol. 32, no. 24, 2007, pages 2585 - 2587
EGHORN, L. F. ET AL.: "Positive allosteric modulation of the GHB high-affinity binding site by the GABAA receptor modulator monastrol and the flavonoid catechin", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 740, 2014, pages 570 - 577, XP55611221
Attorney, Agent or Firm:
SON, Min (KR)
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