Title:
COMPOSITION FOR PREVENTING OR TREATING OSTEOPOROSIS, PREPARATION THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/143221
Kind Code:
A1
Abstract:
A composition for preventing or treating osteoporosis, a preparation thereof, and use thereof in preventing or treating osteoporosis. The composition is mainly composed of a GPX4 agonist and a lipoxygenase 15(Alox-15) inhibitor, and cooperates with vitamin E to exert a synergistic effect. The GPX4 agonist comprises one or more of 6-gingerol, 8-gingerol, 10-gingerol and PKUMDL-LC-101-D04; the Alox-15 inhibitor comprises one or more of quercetin, ferulic acid, baicalein, hesperetin, nobiletin, PD146176, sinensetin and ML351; the composition comprises a ginger extract, a sea-buckthorn extract, and a wheat germ extract.
Inventors:
HE RONGRONG (CN)
LI YIFANG (CN)
KURIHARA HIROSHI (CN)
ZHANG QIONGYI (CN)
JIANG MANYA (CN)
LI YIFANG (CN)
KURIHARA HIROSHI (CN)
ZHANG QIONGYI (CN)
JIANG MANYA (CN)
Application Number:
PCT/CN2023/072505
Publication Date:
August 03, 2023
Filing Date:
January 17, 2023
Export Citation:
Assignee:
UNIV JINAN (CN)
International Classes:
A61K45/00; A23L33/105; A23L33/15; A61K31/12; A61K31/352; A61K31/355; A61K36/9068; A61P19/10
Foreign References:
| CN114225037A | 2022-03-25 | |||
| CN114344289A | 2022-04-15 | |||
| US20190015384A1 | 2019-01-17 | |||
| CN102240388A | 2011-11-16 | |||
| CN110934883A | 2020-03-31 | |||
| RU2007129634A | 2009-02-10 |
Attorney, Agent or Firm:
BEIJING CEMO LEADER INTELLECTUAL PROPERTY AGENCY (CN)
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