COMPOSITION FOR PREVENTING AND TREATING PANCREATITIS CONTAINING NAPHTHOQUINONE-BASED COMPOUND AS ACTIVE INGREDIENT

Title:

COMPOSITION FOR PREVENTING AND TREATING PANCREATITIS CONTAINING NAPHTHOQUINONE-BASED COMPOUND AS ACTIVE INGREDIENT

Document Type and Number:

WIPO Patent Application WO/2016/167622

Kind Code:

A3

Abstract:

The present invention relates to a composition for preventing and treating pancreatitis containing a naphthoquinone-based compound, or a pharmaceutically acceptable salt, prodrug, solvate, or isomer thereof. Specifically, it was verified that β-lapachone and dunnione, which are the naphthoquinone-based compounds, decreased the ratio of pancreatic weight/body weight, the pancreatic weight being increased by pancreatitis, reduced the activity of increased digestive enzymes (amylase and lipase) and the expression of cytokines (IL-1β (interleukin-lβ) and MCP-1), reduced or inhibited inflammation, edema, and cell necrosis of pancreatic tissues, and suppressed the lung damage due to pancreatitis. Therefore, the naphthoquinone-based compound, or the pharmaceutically acceptable salt, prodrug, solvate, or isomer thereof can be favorably used for a composition for preventing and treating pancreatitis.

Inventors:

SO HONG SEOB (KR)
KIM HYUNG-JIN (KR)
SHEN AIHUA (KR)

Application Number:

PCT/KR2016/003998

Publication Date:

December 08, 2016

Filing Date:

April 18, 2016

Export Citation:

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Assignee:

NADIANBIO (KR)

International Classes:

A61K31/352; A61K31/122

Domestic Patent References:

WO2005082354A1	2005-09-09
WO2011035018A2	2011-03-24

Foreign References:

US20050187288A1	2005-08-25
US20050192247A1	2005-09-01
US6114113A	2000-09-05

Other References: