Title:
COMPOSITION FOR PREVENTING OR TREATING STROKE OR DEGENERATIVE BRAIN DISEASE
Document Type and Number:
WIPO Patent Application WO/2014/171583
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing and/or treating a stroke or a degenerative brain disease comprising: at least two substances selected from the group consisting of egg yolk lecithin, glycerol, sodium oleate, medium chain triglyceride and refined fish oil; olive oil; and soybean oil. The composition of the present invention has an excellent neuronal cell protective effect but no toxicity or side effects, and thus can be effectively and safely used for preventing, treating or ameliorating a stroke or a degenerative brain disease.
Inventors:
CHOI JIN GYU (KR)
LEE DONGHUN (KR)
PARK JUYEON (KR)
SONG JUNGBIN (KR)
KIM HOCHEOL (KR)
LEE DONGHUN (KR)
PARK JUYEON (KR)
SONG JUNGBIN (KR)
KIM HOCHEOL (KR)
Application Number:
PCT/KR2013/005301
Publication Date:
October 23, 2014
Filing Date:
June 17, 2013
Export Citation:
Assignee:
NEUMED (KR)
International Classes:
A61K35/56; A61K31/41; A61K35/60; A61P25/00
Domestic Patent References:
| WO2011133841A2 | 2011-10-27 |
Foreign References:
| KR100756890B1 | 2007-09-07 | |||
| US20110044944A1 | 2011-02-24 | |||
| KR20050076324A | 2005-07-26 |
Other References:
SAMIERI, C. ET AL.: "Olive oil consumption, plasma oleic acid, and stroke incidence", NEUROLOGY, vol. 77, no. 5, 2011, pages 418 - 425, XP055279910
TOMSITS, E. ET AL.: "Safety and efficacy of a lipid emulsion containing a mixture of soybean oil, medium-chain triglycerides, olive oil, and fish oil: A randomised, double-blind clinical trial in premature infants requiring parenteral nutrition", JOURNAL OF PEDIATRIC GASTROENTEROLOGY & NUTRITION, vol. 51, no. 4, 2010, pages 514 - 521, XP055279911
KIRINO T; SANO K., ACTA NEUROPATHOL., vol. 62, 1984, pages 201 - 208
KIRINO T., BRAIN RES., vol. 239, 1982, pages 57 - 69
KANG TC ET AL., J.NEUROCYTOL., vol. 30, 2001, pages 945 - 955
WON MH ET AL., BRAIN RES., vol. 836, 1999, pages 70 - 78
SUN AY.; CHEN YM., J.BIOMED. SCI., vol. 5, 1998, pages 401 - 414
FLOWERS F; ZIMMERMAN JJ., NEW HORIZ., vol. 6, 1998, pages 169 - 180
MEDIATORS INFALAMM, 13 November 2012 (2012-11-13), pages 956509
CHIN MED J, vol. 124, no. 21, 2011, pages 3476 - 3480
PHARM RES, vol. 11, 1994, pages 513 517
ENDOCRINOLOGY, vol. 154, 2013, pages 89 - 101
NEUROLOGY, vol. 77, no. 5, 2 August 2011 (2011-08-02), pages 418 - 25
THE SCIENTIFIC WORLD JOURNAL, vol. 10, 2010, pages 1180 - 1191
NEUROSCIENCE LETTERS, vol. 471, 2010, pages 89 - 93
NEUROSCIENCE LETTERS, vol. 464, 2009, pages 93 - 97
ZEA LONGA ET AL., STROKE, vol. 20, 1989, pages 84 - 91
See also references of EP 2987493A4
TOMSITS, E. ET AL.: "Safety and efficacy of a lipid emulsion containing a mixture of soybean oil, medium-chain triglycerides, olive oil, and fish oil: A randomised, double-blind clinical trial in premature infants requiring parenteral nutrition", JOURNAL OF PEDIATRIC GASTROENTEROLOGY & NUTRITION, vol. 51, no. 4, 2010, pages 514 - 521, XP055279911
KIRINO T; SANO K., ACTA NEUROPATHOL., vol. 62, 1984, pages 201 - 208
KIRINO T., BRAIN RES., vol. 239, 1982, pages 57 - 69
KANG TC ET AL., J.NEUROCYTOL., vol. 30, 2001, pages 945 - 955
WON MH ET AL., BRAIN RES., vol. 836, 1999, pages 70 - 78
SUN AY.; CHEN YM., J.BIOMED. SCI., vol. 5, 1998, pages 401 - 414
FLOWERS F; ZIMMERMAN JJ., NEW HORIZ., vol. 6, 1998, pages 169 - 180
MEDIATORS INFALAMM, 13 November 2012 (2012-11-13), pages 956509
CHIN MED J, vol. 124, no. 21, 2011, pages 3476 - 3480
PHARM RES, vol. 11, 1994, pages 513 517
ENDOCRINOLOGY, vol. 154, 2013, pages 89 - 101
NEUROLOGY, vol. 77, no. 5, 2 August 2011 (2011-08-02), pages 418 - 25
THE SCIENTIFIC WORLD JOURNAL, vol. 10, 2010, pages 1180 - 1191
NEUROSCIENCE LETTERS, vol. 471, 2010, pages 89 - 93
NEUROSCIENCE LETTERS, vol. 464, 2009, pages 93 - 97
ZEA LONGA ET AL., STROKE, vol. 20, 1989, pages 84 - 91
See also references of EP 2987493A4
Attorney, Agent or Firm:
AHN, So-Young (KR)
안소영 (KR)
안소영 (KR)
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