Title:
COMPOSITION FOR PREVENTING OR TREATING TISSUE AGING
Document Type and Number:
WIPO Patent Application WO/2023/282145
Kind Code:
A1
Abstract:
Provided is a composition for preventing or treating tissue aging which contains an S-adenosylmethionine synthase inhibitor. Also provided is a method for screening an anti-aging substance, the method comprising (1) a step for culturing fibroblasts in the presence of a candidate compound, (2) a step for evaluating the propagating capability of the fibroblasts, and (3) a step for quantitatively determining the S-adenosylmethionine in the fibroblasts.
Inventors:
NAMIHIRA MASAKAZU (JP)
HAYASHI YOSHIKI (JP)
HAYASHI YOSHIKI (JP)
Application Number:
PCT/JP2022/025977
Publication Date:
January 12, 2023
Filing Date:
June 29, 2022
Export Citation:
Assignee:
AIST (JP)
UNIV TSUKUBA (JP)
UNIV TSUKUBA (JP)
International Classes:
A61K31/519; A61K45/00; A61K31/7105; A61K48/00; A61P15/00; A61P17/00; A61P25/00; A61P43/00; C12N5/071; C12N15/113; C12N15/115; C12N15/85; C12Q1/02; C12Q1/25; G01N33/02; G01N33/15; G01N33/50
Foreign References:
| JP2014512337A | 2014-05-22 | |||
| JP2019529529A | 2019-10-17 |
Other References:
HANSEN MALENE; HSU AO-LIN; DILLIN ANDREW; KENYON CYNTHIA: "New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen", PLOS GENETICS, vol. 1, no. 1, 1 July 2005 (2005-07-01), USA, pages 119 - 128, XP009166048, ISSN: 1553-7390, DOI: 10.1371/journal.pgen.0010017
Attorney, Agent or Firm:
OKUYAMA, Shoichi et al. (JP)
Download PDF: