Title:
COMPOSITION FOR PREVENTION, ALLEVIATION, REDUCTION, OR TREATMENT OF RETINAL DISEASE
Document Type and Number:
WIPO Patent Application WO/2018/236138
Kind Code:
A1
Abstract:
The present invention relates to a use for prevention, alleviation, reduction, or treatment of various retinal diseases and, more particularly, to a compound having a preventive, alleviative, reductive or therapeutic effect on retinal disease or a pharmaceutically acceptable salt thereof, and a use related thereto. A composition for prevention, alleviation, reduction, or treatment of retinal disease according to the present invention suppresses oxidation in retinal pigment epithelial cells and inhibits apoptosis, thereby exhibiting an excellent effect of preventing, alleviating, reducing, and treating various retinal diseases such as macular degeneration, which has various pathological causes. Therefore, the composition of the present invention can find applications in various excellent products for treatment or alleviation of retinal disease, such as medicinal products, health function foods, quasi-drug products, feed additives, etc.
Inventors:
KIM MIN JUNG (KR)
SHIM JAE WON (KR)
PARK JAE HO (KR)
CHOI YUN SANG (KR)
KWAK HAN SUB (KR)
SHIM JAE WON (KR)
PARK JAE HO (KR)
CHOI YUN SANG (KR)
KWAK HAN SUB (KR)
Application Number:
PCT/KR2018/006946
Publication Date:
December 27, 2018
Filing Date:
June 20, 2018
Export Citation:
Assignee:
KOREA FOOD RES INST (KR)
International Classes:
A61K31/37; A23L33/10; A61K9/00; A61K9/08
Domestic Patent References:
| WO2009036656A1 | 2009-03-26 |
Foreign References:
| KR20050017630A | 2005-02-22 |
Other References:
LIU, S.X.L ET AL.: "Facilitation of retinal function recovery by coumarin derivatives", JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, vol. 13, no. 1, February 1997 (1997-02-01), pages 69 - 79, XP002920591, DOI: 10.1089/jop.1997.13.69
INOKUCHI, Y. ET AL.: "Phaysicochemical properties affecting retinal drug/coumarin-6 delivery from nanocarrier systems via eyedrop administration", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE , vol. 51, no. 6, 6 January 2010 (2010-01-06), pages 3162 - 3170, XP055656343, DOI: 10.1167/iovs.09-4697
WATANABE K ET AL: "In vivo imaging of zebrafish retinal cells using fluorescent coumarin derivates", BMC NEUROSCIENCE, vol. 11, no. 116, 15 September 2010 (2010-09-15), pages 1 - 12, XP021073255, DOI: 10.1186/1471-2202-11-116
INOKUCHI, Y. ET AL.: "Phaysicochemical properties affecting retinal drug/coumarin-6 delivery from nanocarrier systems via eyedrop administration", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE , vol. 51, no. 6, 6 January 2010 (2010-01-06), pages 3162 - 3170, XP055656343, DOI: 10.1167/iovs.09-4697
WATANABE K ET AL: "In vivo imaging of zebrafish retinal cells using fluorescent coumarin derivates", BMC NEUROSCIENCE, vol. 11, no. 116, 15 September 2010 (2010-09-15), pages 1 - 12, XP021073255, DOI: 10.1186/1471-2202-11-116
Attorney, Agent or Firm:
YOON & YANG (IP) LLC (KR)
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