Title:
COMPOSITION FOR PREVENTION, AMELIORATION OR TREATMENT OF MUSCLE DISEASES COMPRISING GINSENOSIDE RC
Document Type and Number:
WIPO Patent Application WO/2023/027540
Kind Code:
A1
Abstract:
The present invention relates to a composition for the prevention, amelioration or treatment of muscle diseases, comprising ginsenoside Rc. Ginsenoside Rc inhibits myoblast apoptosis under oxidative stress, increases the activity of PGC1-α, which is a metabolic regulator and a mitochondrial biogenesis factor, in myoblasts and myotubes, inhibits a reduction in PGC1-α and MyH in myotubes, maintains mitochondrial mass, and suppresses muscle damage caused by oxidative stress by inhibiting an increase in MuRF and MAFbx, which are proteins involved in muscle cell breakdown, and thus can be used for the prevention, amelioration or treatment of muscle diseases, in particular, muscle diseases caused by decreased muscular function, muscle wasting, or muscular degeneration.
More Like This:
Inventors:
KIM AEYUNG (KR)
KIM NO SOO (KR)
LEE HAESEUNG (KR)
KIM NO SOO (KR)
LEE HAESEUNG (KR)
Application Number:
PCT/KR2022/012781
Publication Date:
March 02, 2023
Filing Date:
August 26, 2022
Export Citation:
Assignee:
KOREA INST ORIENTAL MEDICINE (KR)
International Classes:
A61K31/704; A23L33/125; A61P21/00
Foreign References:
| CN102125594A | 2011-07-20 | |||
| KR20210050475A | 2021-05-07 | |||
| KR20190108777A | 2019-09-25 | |||
| KR101917794B1 | 2018-11-13 | |||
| KR20210074901A | 2021-06-22 |
Attorney, Agent or Firm:
HANOL INTELLECTUAL PROPERTY & LAW (KR)
Download PDF: