Title:
COMPOSITION FOR PREVENTION OR TREATMENT OF INTRACTABLE EPILEPSY COMPRISING MTOR INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2016/144066
Kind Code:
A3
Abstract:
The present invention relates to prevention, improvement or treatment of intractable epilepsy, for example focal cortical dysplasia (FCD).
Inventors:
LEE JEONG HO (KR)
LIM JAE SEOK (KR)
KIM WOO-IL (KR)
KIM DONG SEOK (KR)
KANG HOON CHUL (KR)
KIM SE HOON (KR)
LIM JAE SEOK (KR)
KIM WOO-IL (KR)
KIM DONG SEOK (KR)
KANG HOON CHUL (KR)
KIM SE HOON (KR)
Application Number:
PCT/KR2016/002248
Publication Date:
October 27, 2016
Filing Date:
March 07, 2016
Export Citation:
Assignee:
KOREA ADVANCED INST SCI & TECH (KR)
YONSEI UNIV UNIV - IND FOUND (UIF) (KR)
YONSEI UNIV UNIV - IND FOUND (UIF) (KR)
International Classes:
A61K31/436; A01K67/027; A61K31/4375; A61K31/497; A61K31/519; A61K31/5377; C12N15/85; C12Q1/68; G01N33/68
Foreign References:
| US20150065380A1 | 2015-03-05 | |||
| KR20070116555A | 2007-12-10 |
Other References:
LJUNGBERG, M. C. ET AL.: "Rapamycin suppresses Seizures and Neuronal Hypertrophy in a Mouse Model of Cortical Dysplasia", DISEASE MODELS AND MECHANISMS, vol. 2, no. 7-8, 2009, pages 389 - 398, XP055323889
D'GAMA, A. M. ET AL.: "Mammalian Target of Rapamycin Pathway Mutations cause Hemimegalencephaly and Focal Cortical Dysplasia", ANNALS OF NEUROLOGY, vol. 77, 26 February 2015 (2015-02-26), pages 720 - 725, XP055323904
SANCAK, O. ET AL.: "Mutational Analysis of the TSC1 and TSC2 Genes in a Diagnostic Setting: Genotype-phenotype Correlations and Comparison of Diagnostic DNA Techniques in Tuberous Sclerosis Complex", EUROPEAN JOURNAL OF HUMAN GENETICS, vol. 13, 2005, pages 731 - 741, XP055323910
D'GAMA, A. M. ET AL.: "Mammalian Target of Rapamycin Pathway Mutations cause Hemimegalencephaly and Focal Cortical Dysplasia", ANNALS OF NEUROLOGY, vol. 77, 26 February 2015 (2015-02-26), pages 720 - 725, XP055323904
SANCAK, O. ET AL.: "Mutational Analysis of the TSC1 and TSC2 Genes in a Diagnostic Setting: Genotype-phenotype Correlations and Comparison of Diagnostic DNA Techniques in Tuberous Sclerosis Complex", EUROPEAN JOURNAL OF HUMAN GENETICS, vol. 13, 2005, pages 731 - 741, XP055323910
Attorney, Agent or Firm:
YOU ME PATENT AND LAW FIRM (Gangnam-gu, Seoul, KR)
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