Title:
COMPOSITION FOR PREVENTION OR TREATMENT OF KIDNEY DISEASE
Document Type and Number:
WIPO Patent Application WO/2022/169279
Kind Code:
A1
Abstract:
Kidney organ-derived stem cells or organoids according to the present disclosure: are easy to apply to a therapeutic procedure; can be supplied in a large amount due to the high self-proliferation rate thereof; have a high potential to differentiate into renal cells; are highly unlikely to form a tumor; and have an excellent ability to regenerate damaged tissues when directly injected into a lesion. Therefore, the stem cells can be very appropriately used for adult stem cell-based regenerative therapy, inter alia. In addition, a composition according to the present invention can specifically select only renal stem cells among renal cells. Furthermore, renal stem cells expressing Lrig1 protein or a gene coding therefor are superb in terms of renewal ability and pluripotency and possess the potential of differentiating to nephrons and as such, can find very effective applications in preventing or treating kidney diseases.
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Inventors:
NAM KI TAEK (KR)
LEE YURA (KR)
LEE YURA (KR)
Application Number:
PCT/KR2022/001727
Publication Date:
August 11, 2022
Filing Date:
February 04, 2022
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
International Classes:
A61K35/22; A01K67/027; A61K38/17; A61P13/12; C07K14/47; C12N5/071; C12Q1/686; G01N33/569; G01N33/68
Domestic Patent References:
| WO2020022261A1 | 2020-01-30 |
Foreign References:
| CN105664179A | 2016-06-15 | |||
| JP2018526010A | 2018-09-13 | |||
| KR20200086665A | 2020-07-17 | |||
| JP2016513469A | 2016-05-16 |
Other References:
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RYUJI MORIZANE, ALBERT Q LAM, BENJAMIN S FREEDMAN, SEIJI KISHI, M TODD VALERIUS, JOSEPH V BONVENTRE: "Nephron organoids derived from human pluripotent stem cells model kidney development and injury", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 33, no. 11, 1 November 2015 (2015-11-01), New York, pages 1193 - 1200, XP055539523, ISSN: 1087-0156, DOI: 10.1038/nbt.3392
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SCHWEIGER PAWEL J., CLEMENT DITTE L., PAGE MAHALIA E., SCHEPELER TROELS, ZOU XIANGANG, SIROKMÁNY GABOR, WATT FIONA M., JENSEN KIM : "Lrig1 marks a population of gastric epithelial cells capable of long-term tissue maintenance and growth in vitro", SCIENTIFIC REPORTS, vol. 8, no. 1, 1 December 2018 (2018-12-01), pages 15255, XP055955264, DOI: 10.1038/s41598-018-33578-6
CRISTINA FUENTE MORA, EGON RANGHINI, STEFANIA BRUNO, BENEDETTA BUSSOLATI, GIOVANNI CAMUSSI, BETTINA WILM, DAVID EDGAR, SIMON E. KE: "Differentiation of Podocyte and Proximal Tubule-Like Cells from a Mouse Kidney-Derived Stem Cell Line", STEM CELLS AND DEVELOPMENT, vol. 21, no. 2, 20 January 2012 (2012-01-20), pages 296 - 307, XP055185394, ISSN: 15473287, DOI: 10.1089/scd.2010.0470
BOCK L C ET AL., NATURE, vol. 355, no. 6360, 1992, pages 5646
HOPPE-SEYLER FBUTZ K: "Peptide aptamers: powerful new tools for molecular medicine", J MOL MED., vol. 78, no. 8, 2000, pages 42630, XP002413234, DOI: 10.1007/s001090000140
COHEN B ACOLAS PBRENT R: "An artificial cell-cycle inhibitor isolated from a combinatorial library", PROC NATL ACAD SCI USA., vol. 95, no. 24, 1998, pages 142727
LAB ANIM RES. DEC, vol. 34, no. 4, 2018, pages 147 - 159
RYUJI MORIZANE, ALBERT Q LAM, BENJAMIN S FREEDMAN, SEIJI KISHI, M TODD VALERIUS, JOSEPH V BONVENTRE: "Nephron organoids derived from human pluripotent stem cells model kidney development and injury", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 33, no. 11, 1 November 2015 (2015-11-01), New York, pages 1193 - 1200, XP055539523, ISSN: 1087-0156, DOI: 10.1038/nbt.3392
THOMASSON M, HEDMAN H, GUO D, LJUNGBERG B, HENRIKSSON R: "LRIG1 and epidermal growth factor receptor in renal cell carcinoma: a quantitative RT–PCR and immunohistochemical analysis", BRITISH JOURNAL OF CANCER, NATURE PUBLISHING GROUP UK, LONDON, vol. 89, no. 7, 6 October 2003 (2003-10-06), London, pages 1285 - 1289, XP055955267, ISSN: 0007-0920, DOI: 10.1038/sj.bjc.6601208
SCHWEIGER PAWEL J., CLEMENT DITTE L., PAGE MAHALIA E., SCHEPELER TROELS, ZOU XIANGANG, SIROKMÁNY GABOR, WATT FIONA M., JENSEN KIM : "Lrig1 marks a population of gastric epithelial cells capable of long-term tissue maintenance and growth in vitro", SCIENTIFIC REPORTS, vol. 8, no. 1, 1 December 2018 (2018-12-01), pages 15255, XP055955264, DOI: 10.1038/s41598-018-33578-6
CRISTINA FUENTE MORA, EGON RANGHINI, STEFANIA BRUNO, BENEDETTA BUSSOLATI, GIOVANNI CAMUSSI, BETTINA WILM, DAVID EDGAR, SIMON E. KE: "Differentiation of Podocyte and Proximal Tubule-Like Cells from a Mouse Kidney-Derived Stem Cell Line", STEM CELLS AND DEVELOPMENT, vol. 21, no. 2, 20 January 2012 (2012-01-20), pages 296 - 307, XP055185394, ISSN: 15473287, DOI: 10.1089/scd.2010.0470
BOCK L C ET AL., NATURE, vol. 355, no. 6360, 1992, pages 5646
HOPPE-SEYLER FBUTZ K: "Peptide aptamers: powerful new tools for molecular medicine", J MOL MED., vol. 78, no. 8, 2000, pages 42630, XP002413234, DOI: 10.1007/s001090000140
COHEN B ACOLAS PBRENT R: "An artificial cell-cycle inhibitor isolated from a combinatorial library", PROC NATL ACAD SCI USA., vol. 95, no. 24, 1998, pages 142727
LAB ANIM RES. DEC, vol. 34, no. 4, 2018, pages 147 - 159
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PADO IP LAW PLLC (KR)
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