Title:
COMPOSITION FOR PREVENTION AND TREATMENT OF MUSCLE DISEASE, CONTAINING MAGNOLIAE CORTEX EXTRACT AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2023/153533
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for treatment of muscle disease, containing a Magnoliae Cortex extract, the Magnoliae Cortex extract containing various components other than magnolol and honokiol, and not interfering with an antitumor function while inhibiting cisplatin-induced weight loss, muscle mass reduction, grip strength reduction, and muscle fiber damage, and promoting the repair of damaged muscle fibers through macrophage polarization from M1 to M2, and thus being usefully employable for the purpose of prevention and treatment of muscle disease, and especially, anticancer drug-induced muscle disease.
Inventors:
HONG MIN WOO (KR)
HAN IK HWAN (KR)
CHOI IL SEOB (KR)
CHA NA RI (KR)
KIM WOO JIN (KR)
KIM SUN KWANG (KR)
BAE HYUN SU (KR)
HAN IK HWAN (KR)
CHOI IL SEOB (KR)
CHA NA RI (KR)
KIM WOO JIN (KR)
KIM SUN KWANG (KR)
BAE HYUN SU (KR)
Application Number:
PCT/KR2022/001982
Publication Date:
August 17, 2023
Filing Date:
February 09, 2022
Export Citation:
Assignee:
TWINPIGBIOLAB INC (KR)
International Classes:
A23L33/105; A61K36/54; A61P21/00
Foreign References:
| KR20090110602A | 2009-10-22 | |||
| KR20170001681A | 2017-01-04 |
Other References:
LEE CHANJU, JEONG HYUNJU, LEE HYUNJI, HONG MINWOO, PARK SEON-YOUNG, BAE HYUNSU: "Magnolol Attenuates Cisplatin-Induced Muscle Wasting by M2c Macrophage Activation", FRONTIERS IN IMMUNOLOGY, vol. 11, 7 February 2020 (2020-02-07), pages 77, XP093084684, DOI: 10.3389/fimmu.2020.00077
LIN YIPING, LI YUKE, ZENG YUANLIAN, TIAN BIN, QU XIAOLAN, YUAN QIANGHUA, SONG YING: "Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update", FRONTIERS IN PHARMACOLOGY, vol. 12, pages 632767, XP093084693, DOI: 10.3389/fphar.2021.632767
HONG MINWOO, HAN IK-HWAN, CHOI ILSEOB, CHA NARI, KIM WOOJIN, KIM SUN KWANG, BAE HYUNSU: "Magnoliae Cortex Alleviates Muscle Wasting by Modulating M2 Macrophages in a Cisplatin-Induced Sarcopenia Mouse Model", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, no. 6, 20 March 2021 (2021-03-20), pages 3188, XP093084734, DOI: 10.3390/ijms22063188
LIN YIPING, LI YUKE, ZENG YUANLIAN, TIAN BIN, QU XIAOLAN, YUAN QIANGHUA, SONG YING: "Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update", FRONTIERS IN PHARMACOLOGY, vol. 12, pages 632767, XP093084693, DOI: 10.3389/fphar.2021.632767
HONG MINWOO, HAN IK-HWAN, CHOI ILSEOB, CHA NARI, KIM WOOJIN, KIM SUN KWANG, BAE HYUNSU: "Magnoliae Cortex Alleviates Muscle Wasting by Modulating M2 Macrophages in a Cisplatin-Induced Sarcopenia Mouse Model", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, no. 6, 20 March 2021 (2021-03-20), pages 3188, XP093084734, DOI: 10.3390/ijms22063188
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
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