Title:
COMPOSITION FOR PREVENTION OR TREATMENT OF NOVEL CORONAVIRUS INFECTION COMPRISING SESQUITERPENOID-BASED COMPOUND OBTAINED FROM PSIDIUMA GUAJAVA LEAF EXTRACT OR FRACTION THEREOF AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2023/022523
Kind Code:
A1
Abstract:
The present invention relates to a composition for the prevention or treatment of novel coronavirus infection, the composition comprising a Psidiuma guajava leaf extract and a fraction thereof, or sesquiterpenoid-based and porphyrin-based compounds isolated therefrom, as an active ingredient. Through synergistic antiviral activity obtained by increasing the amount of an active ingredient derived from a Psidiuma guajava leaf extract and combining the isolated active compounds, the composition can be effectively used in, in particular, the treatment and prevention of novel coronavirus infection.
Inventors:
OH WON KEUN (KR)
RYU BYEOL (KR)
LEE BA WOOL (KR)
CHO HYO MOON (KR)
PARK EUN JIN (KR)
CHOI YOUNG KI (KR)
KIM EUN HA (KR)
RYU BYEOL (KR)
LEE BA WOOL (KR)
CHO HYO MOON (KR)
PARK EUN JIN (KR)
CHOI YOUNG KI (KR)
KIM EUN HA (KR)
Application Number:
PCT/KR2022/012302
Publication Date:
February 23, 2023
Filing Date:
August 17, 2022
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
NAT UNIV CHUNGBUK IND ACAD COOP FOUND (KR)
NAT UNIV CHUNGBUK IND ACAD COOP FOUND (KR)
International Classes:
A61K36/61; A23K10/30; A23K20/105; A23K20/121; A23L33/105; A61K31/015; A61K31/045; A61K31/352; A61K31/409; A61P31/14
Foreign References:
| KR20110065534A | 2011-06-15 | |||
| KR101007929B1 | 2011-01-14 | |||
| KR20190053490A | 2019-05-20 |
Other References:
KAZI FAIZUL AZIM, SHEIKH RASHEL AHMED, ANIK BANIK, MD MOSTAFIGUR RAHMAN KHAN, ANAMIKA DEB: "Screening and druggability analysis of some plant metabolites against SARS-CoV-2: An integrative computational approach", CHEMRXIV, AMERICAN CHEMICAL SOCIETY, WASHINGTON, 5 May 2020 (2020-05-05), Washington, XP055943891, Retrieved from the Internet [retrieved on 20220719], DOI: 10.26434/chemrxiv.12235949.v1
RYU BYEOL, CHO HYO MOON, ZHANG MI, LEE BA WOOL, DOAN THI PHUONG, PARK EUN JIN, LEE HEE JU, OH WON KEUN: "Meroterpenoids from the leaves of Psidium guajava (guava) cultivated in Korea using MS/MS-based molecular networking", PHYTOCHEMISTRY, ELSEVIER, AMSTERDAM , NL, vol. 186, 1 June 2021 (2021-06-01), Amsterdam , NL , pages 112723, XP055975567, ISSN: 0031-9422, DOI: 10.1016/j.phytochem.2021.112723
KIM EUN-HA, LEE BA WOOL, RYU BYEOL, CHO HYO MOON, KIM SE-MI, JANG SEUNG-GYU, CASEL MARK ANTHONY B., ROLLON RARE, YOO JI-SEUNG, POO: "Inhibition of a broad range of SARS-CoV-2 variants by antiviral phytochemicals in hACE2 mice", ANTIVIRAL RESEARCH, ELSEVIER BV, NL, vol. 204, 1 August 2022 (2022-08-01), NL , pages 105371, XP093037368, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2022.105371
RYU BYEOL, CHO HYO MOON, ZHANG MI, LEE BA WOOL, DOAN THI PHUONG, PARK EUN JIN, LEE HEE JU, OH WON KEUN: "Meroterpenoids from the leaves of Psidium guajava (guava) cultivated in Korea using MS/MS-based molecular networking", PHYTOCHEMISTRY, ELSEVIER, AMSTERDAM , NL, vol. 186, 1 June 2021 (2021-06-01), Amsterdam , NL , pages 112723, XP055975567, ISSN: 0031-9422, DOI: 10.1016/j.phytochem.2021.112723
KIM EUN-HA, LEE BA WOOL, RYU BYEOL, CHO HYO MOON, KIM SE-MI, JANG SEUNG-GYU, CASEL MARK ANTHONY B., ROLLON RARE, YOO JI-SEUNG, POO: "Inhibition of a broad range of SARS-CoV-2 variants by antiviral phytochemicals in hACE2 mice", ANTIVIRAL RESEARCH, ELSEVIER BV, NL, vol. 204, 1 August 2022 (2022-08-01), NL , pages 105371, XP093037368, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2022.105371
Attorney, Agent or Firm:
GHONG-GAN INTERNATIONAL PATENT LAW FIRM (KR)
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