Title:
COMPOSITION FOR PRODUCING 3-HYDROXY PHLORETIN
Document Type and Number:
WIPO Patent Application WO/2019/066446
Kind Code:
A9
Abstract:
The present invention relates to a wild-type CYP102A1 mutant for producing 3-hydroxy phloretin among metabolites of phloretin, and can mass-produce 3-hydroxy phloretin by oxidizing phloretin by using, as catalysts, a point mutant of wild-type CYP102A1 which is a bacterial cytochrome P450 enzyme, CYP102A1 chimera obtained by fusing a heme domain of the point mutant of the wild-type CYP102A1 with a reductase of a natural variant of the wild-type CYP102A1, and a point mutant of the CYP102A1 chimera.
Inventors:
YUN CHUL-HO (KR)
NGUYEN NGOC ANH (KR)
LE THIEN KIM (KR)
KANG HYUNG-SIK (KR)
NGUYEN NGOC ANH (KR)
LE THIEN KIM (KR)
KANG HYUNG-SIK (KR)
Application Number:
PCT/KR2018/011350
Publication Date:
July 11, 2019
Filing Date:
September 27, 2018
Export Citation:
Assignee:
UNIV NAT CHONNAM IND FOUND (KR)
International Classes:
C12N9/02; C12P7/26
Attorney, Agent or Firm:
PLUS INTERNATIONAL IP LAW FIRM (KR)
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