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Title:
COMPOSITION FOR PROMOTING ANGIOGENESIS, CONTAINING AC-PGP PEPTIDE AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2017/217728
Kind Code:
A1
Abstract:
The present invention relates to: a composition for promoting angiogenesis, a pharmaceutical composition for preventing or treating angiogenesis-dependent diseases, and a quasi-drug and cosmetic composition for skin regeneration, all of the compositions containing, as an active ingredient, an acetylated Pro-Gly-Pro (Ac-PGP) peptide, or an Ac-PGP peptide and endothelial progenitor cells; and a method for promoting angiogenesis, a method for preventing or treating angiogenesis-dependent diseases, and a method for skin regeneration, all of the methods comprising the step of administering an Ac-PGP peptide, or an Ac-PGP peptide and endothelial progenitor cells, to an individual in need thereof.

Inventors:
KIM JAE HO (KR)
KWON YANG WOO (KR)
Application Number:
PCT/KR2017/006124
Publication Date:
December 21, 2017
Filing Date:
June 13, 2017
Export Citation:
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Assignee:
PUSAN NATIONAL UNIV INDUSTRYUNIV COOPERATION FOUNDATION (KR)
International Classes:
A61K38/06; A61K8/64; A61K8/98; A61K35/44; A61Q19/00; C07K5/097
Domestic Patent References:
WO2016077365A12016-05-19
Foreign References:
KR101247641B12013-03-29
US20040176304A12004-09-09
US20020107202A12002-08-08
Other References:
HAHN ET AL.: "The Matrikine N-alpha-PGP Couples Extracellular Matrix Fragmentation to Endothelial Permeability", SCIENCE ADVANCES, vol. 1, no. e1500175, 24 April 2015 (2015-04-24), pages 1 - 10, XP055447955
KWON ET AL.: "N-acetylated Proline-Glycine-Proline Accelerates Cutaneous Wound Healing and Neovascularization by Human Endothelial Progenitor Cells", SCIENTIFIC REPORTS, vol. 7, no. 43057, 23 February 2017 (2017-02-23), pages 1 - 13, XP055447957
KWON ET AL.: "CXCR2-specific Peptide Acetylated Pro-Gly-Pro (Ac-PGP) Stimulates Wound Healing by Promoting Neovasculogenesis", ANNUAL MEETING, 22 June 2016 (2016-06-22), San Francisco, USA
Attorney, Agent or Firm:
KIM, Soon Woong (KR)
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