Title:
COMPOSITION FOR PROMOTING ANTIMICROBIAL PEPTIDE PRODUCTION
Document Type and Number:
WIPO Patent Application WO/2020/111172
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel material that elevates the production of antimicrobial peptides from epithelial cells and has a preventative effect against infection. The present invention provides a composition for promoting antimicrobial peptide production, the composition having lactic acid bacteria of the genus Lactobacillus as an active ingredient. The present invention also provides a composition for promoting antimicrobial peptide production, the composition having a component derived from Lactobacillus cells as an active ingredient. Furthermore, the present invention provides a composition for promoting antimicrobial peptide production in which the bacterial-cell-derived component is one or more selected from the group consisting of S-layer proteins and S-layer protein degradation products.
Inventors:
KOBATAKE EIJI (JP)
KABUKI TOSHIHIDE (JP)
KABUKI TOSHIHIDE (JP)
Application Number:
PCT/JP2019/046527
Publication Date:
June 04, 2020
Filing Date:
November 28, 2019
Export Citation:
Assignee:
MEGMILK SNOW BRAND CO LTD (JP)
International Classes:
A61P31/04; A23L33/18; A23L33/195; A61K38/16; A61K35/744
Domestic Patent References:
| WO2015087919A1 | 2015-06-18 |
Foreign References:
| JP2015083547A | 2015-04-30 | |||
| JP2015151385A | 2015-08-24 | |||
| JP5224807B2 | 2013-07-03 | |||
| JP2003095938A | 2003-04-03 |
Other References:
PRADO ACOSTA, M. ET AL.: "S-layer proteins from Lactobacillus sp. inhibit bacterial infection by blockage of DC-SIGN cell receptor", INT. J. BIOL. MACROMOL., vol. 92, November 2016 (2016-11-01), pages 998 - 1005, XP029755328, DOI: 10.1016/j.ijbiomac.2016.07.096
MARTINEZ, M. G. ET AL.: "S-layer proteins of Lactobacillus acidophilus inhibits JUNV infection", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 422, no. 4, 15 June 2012 (2012-06-15), pages 590 - 595, XP055712692
KOBATAKE, E. ET AL.: "S-Layer Protein of Lactobacillus helveticus SBT2171 Promotes Human beta- Defensin 2 Expression via TLR2-JNK Signaling", FRONT. MICROBIOL., vol. 10, no. 2414, 18 October 2019 (2019-10-18), pages 1 - 12, XP055712697
MUKAI ET AL., JAPANESE JOURNAL OF LACTIC ACID BACTERIA, vol. 19, no. 1, 2008, pages 21 - 29
See also references of EP 3888754A4
MARTINEZ, M. G. ET AL.: "S-layer proteins of Lactobacillus acidophilus inhibits JUNV infection", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 422, no. 4, 15 June 2012 (2012-06-15), pages 590 - 595, XP055712692
KOBATAKE, E. ET AL.: "S-Layer Protein of Lactobacillus helveticus SBT2171 Promotes Human beta- Defensin 2 Expression via TLR2-JNK Signaling", FRONT. MICROBIOL., vol. 10, no. 2414, 18 October 2019 (2019-10-18), pages 1 - 12, XP055712697
MUKAI ET AL., JAPANESE JOURNAL OF LACTIC ACID BACTERIA, vol. 19, no. 1, 2008, pages 21 - 29
See also references of EP 3888754A4
Attorney, Agent or Firm:
MOEGI PATENT OFFICE (JP)
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