COMPOSITION FOR PROMOTING CILIOGENESIS COMPRISING NOVEL FABP4 INHIBITOR AS ACTIVE INGREDIENT

Title:

COMPOSITION FOR PROMOTING CILIOGENESIS COMPRISING NOVEL FABP4 INHIBITOR AS ACTIVE INGREDIENT

Document Type and Number:

WIPO Patent Application WO/2022/169004

Kind Code:

A1

Abstract:

The present invention relates to a composition for the prevention or treatment of ciliopathy and metabolic disorder, the composition comprising a novel pyrazole derivative that inhibits FABP4, as an active ingredient. The composition of the present invention remarkably increases the expression of ciliogenesis-related proteins and the number of ciliated cells, and thus can be effectively used as a fundamental and safe non-genetic therapeutic agent for various ciliopathy caused by ciliogenesis deficiency, abnormal ciliogenesis, and ciliary dysfunction. The composition of the present invention also significantly inhibits the expression or activity of FABP4 in a dose-dependent manner, and thus can also be used as an efficient therapeutic composition for various metabolic disorders caused by disorders of lipid metabolism.

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Inventors:

KWON HO JEONG (KR)
JUNG YOOJU (KR)

Application Number:

PCT/KR2021/001593

Publication Date:

August 11, 2022

Filing Date:

February 05, 2021

Export Citation:

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Assignee:

UNIV YONSEI IACF (KR)

International Classes:

A61K31/454; A23L33/10; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P35/00; A61P43/00

Domestic Patent References:

WO2020163337A1	2020-08-13
WO2005061462A2	2005-07-07

Foreign References:

US20200138779A1	2020-05-07
US20070276001A1	2007-11-29
KR20210098732A	2021-08-11

Other References:

SHI MIN, HUANG RONGSHUANG, GUO FAN, LI LINGZHI, FENG YANHUAN, WEI ZHENGJIE, ZHOU LI, MA LIANG, FU PING: "Pharmacological inhibition of fatty acid-binding protein 4 (FABP4) protects against renal ischemia-reperfusion injury", RSC ADVANCES, vol. 8, no. 27, 1 January 2018 (2018-01-01), pages 15207 - 15214, XP055957143, DOI: 10.1039/C8RA00122G

Attorney, Agent or Firm:

CHUNG HYUN PATENT & LAW FIRM (KR)

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