Title:
COMPOSITION FOR PROMOTING DIFFERENTIATION OF SKIN CELLS AND METHOD FOR SCREENING FOR MATERIALS PROMOTING DIFFERENTIATION OF SKIN CELLS
Document Type and Number:
WIPO Patent Application WO/2017/171249
Kind Code:
A1
Abstract:
Disclosed in the present specification are a composition for promoting the differentiation of skin cells and a method for screening for materials promoting the differentiation of skin cells. The composition for promoting the differentiation of skin cells, of the present invention, inhibits the expression or activity of JAB-1, thereby inhibiting the migration of psoriasin into the cell nucleus so as to enable the differentiation of skin cells to be effectively promoted. Therefore, the composition is effective in skin moisturization, skin barrier function strengthening, or treatment for atopy alleviation. In addition, according to one aspect, the method for screening for materials promoting the differentiation of skin cells treats keratinocytes with test materials and identifies the relative expression levels of JAB-1, thereby enabling materials for promoting the differentiation of corneocytes to be conveniently, rapidly and efficiently screened for.
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Inventors:
SON EUI DONG (KR)
KIM HYOUNG JUNE (KR)
KIM KYU HAN (KR)
PARK SUN YOUNG (KR)
LEE SUNG HOON (KR)
CHOI MIN SIK (KR)
CHO EUN-GYUNG (KR)
LEE TAE RYONG (KR)
KIM HYOUNG JUNE (KR)
KIM KYU HAN (KR)
PARK SUN YOUNG (KR)
LEE SUNG HOON (KR)
CHOI MIN SIK (KR)
CHO EUN-GYUNG (KR)
LEE TAE RYONG (KR)
Application Number:
PCT/KR2017/002211
Publication Date:
October 05, 2017
Filing Date:
February 28, 2017
Export Citation:
Assignee:
AMOREPACIFIC CORP (KR)
International Classes:
A61K48/00; A23L33/13; A61K8/60; A61K31/713; G01N33/50; G01N33/68
Domestic Patent References:
| WO2014167030A1 | 2014-10-16 |
Other References:
CALANDRA, THIERRY ET AL.: "Macrophage Migration Inhibitory Factor: A Regulator of Innate Immunity", NATURE REVIEWS IMMUNOLOGY, vol. 3, 2003, pages 79, XP055430236
WEBB, MEGHAN ET AL.: "Expression Analysis of the Mouse S 100A7 /psoriasin Gene in Skin Inflammation and Mammary Tumorigenesis", BMC CANCER, vol. 5, 2005, pages 1 - 16, XP021004775
EMBERLEY, ETHAN D. ET AL.: "The S 100A7 -c-Jun Activation Domain Binding Protein 1 Pathway Enhances Prosurvival Pathways in Breast Cancer", CANCER RESEARCH, vol. 65, no. 13, 2005, pages 5696 - 5702, XP055533222
GESSER, B.: "Dimethylfumarate Inhibits MIF-induced Proliferation of Keratinocytes by Inhibiting MSK1 and RSK1 Activation and by Inducing Nuclear pc-Jun (S63) and p-p53 (S15) Expression", INFLAMMATION RESEARCH, vol. 60, 2011, pages 643 - 653, XP019916954
See also references of EP 3437663A4
WEBB, MEGHAN ET AL.: "Expression Analysis of the Mouse S 100A7 /psoriasin Gene in Skin Inflammation and Mammary Tumorigenesis", BMC CANCER, vol. 5, 2005, pages 1 - 16, XP021004775
EMBERLEY, ETHAN D. ET AL.: "The S 100A7 -c-Jun Activation Domain Binding Protein 1 Pathway Enhances Prosurvival Pathways in Breast Cancer", CANCER RESEARCH, vol. 65, no. 13, 2005, pages 5696 - 5702, XP055533222
GESSER, B.: "Dimethylfumarate Inhibits MIF-induced Proliferation of Keratinocytes by Inhibiting MSK1 and RSK1 Activation and by Inducing Nuclear pc-Jun (S63) and p-p53 (S15) Expression", INFLAMMATION RESEARCH, vol. 60, 2011, pages 643 - 653, XP019916954
See also references of EP 3437663A4
Attorney, Agent or Firm:
KIM, Sun-young (KR)
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