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Title:
COMPOSITION FOR PROMOTING PRODUCTION OF IMMUNOSTIMULATORY FACTOR
Document Type and Number:
WIPO Patent Application WO/2018/025793
Kind Code:
A1
Abstract:
This composition, for promoting immunostimulatory factor production, contains the genomic double-stranded RNA of a plant-derived endornavirus, and can prevent and improve a variety of diseases such as viral diseases, cancer and multiple sclerosis.

Inventors:
FUJITA, Takashi (36-1 Yoshida-honmachi, Sakyo-ku, Kyoto-sh, Kyoto 01, 〒6068501, JP)
KATO, Hiroki (36-1 Yoshida-honmachi, Sakyo-ku, Kyoto-sh, Kyoto 01, 〒6068501, JP)
NAKAZAKI, Tetsuya (36-1 Yoshida-honmachi, Sakyo-ku, Kyoto-sh, Kyoto 01, 〒6068501, JP)
Application Number:
JP2017/027638
Publication Date:
February 08, 2018
Filing Date:
July 31, 2017
Export Citation:
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Assignee:
KYOTO UNIVERSITY (36-1, Yoshida-honmachi Sakyo-ku, Kyoto-sh, Kyoto 01, 〒6068501, JP)
International Classes:
A61K31/713; A23L33/13; A61K35/76; A61K36/48; A61K36/81; A61K36/899; A61K39/39; A61P31/12; A61P31/14; A61P35/00; A61P37/04
Domestic Patent References:
2012-02-02
Foreign References:
CN104174029A2014-12-03
Other References:
LAI YVONNE ET AL.: "LL37 and cationic peptides enhance TLR3 signaling by viral double-stranded RNAs", PLOS ONE, vol. 6, no. 10, 2011, pages e26632, XP055461970, ISSN: 1932-6203
TOSHIYUKI FUKUHARA: "Unique symbiotic viruses in plants: Endornaviruses", VIRUS, vol. 65, no. 2, 2015, pages 209 - 218, XP055461973, ISSN: 0042-6857
DING SHOU-WEI: "RNA-based antiviral immunity", NAT.REV.IMMUNOL., vol. 10, no. 9, 2010, pages 632 - 644, XP055462021, ISSN: 1474-1733
KATO HIROKI ET AL.: "Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses", NATURE, vol. 441, no. 7089, 2006, pages 101 - 105, XP003017391, ISSN: 0028-0836
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (Kitahama TNK Building, 1-7-1 Doshomachi, Chuo-ku, Osaka-sh, Osaka 45, 〒5410045, JP)
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