Title:
COMPOSITION FOR RESTRAINING ACTIVITY OF REGULATORY T CELL, COMPRISING PEPTIDE BINDING SPECIFICALLY TO NEUROPILIN 1 (NRP1)
Document Type and Number:
WIPO Patent Application WO/2019/050326
Kind Code:
A1
Abstract:
The present invention relates to a composition for inhibiting the immunosuppression of regulatory T cells (Treg), using a fusion protein inclusive of a peptide binding specifically to neuropilin 1 (NRP1). A fusion protein inclusive of a peptide binding specifically to neuropilin 1 according to the present invention reduces a proportion of regulatory T cells of CD4+ T cells in a tumor tissue and restrains the activity of regulatory T cells that have penetrated into a tumor tissue, thereby downregulating the immunosuppression in the tumor tissue without systemic toxicity and thus can be expected to exert a high therapeutic effect on a tumor.
Inventors:
KIM YONG SUNG (KR)
KIM YE JIN (KR)
JUNG KEUNOK (KR)
KIM JEONG-AH (KR)
KIM YE JIN (KR)
JUNG KEUNOK (KR)
KIM JEONG-AH (KR)
Application Number:
PCT/KR2018/010487
Publication Date:
March 14, 2019
Filing Date:
September 07, 2018
Export Citation:
Assignee:
UNIV AJOU IND ACADEMIC COOP FOUND (KR)
International Classes:
C07K7/08; A61K38/00; A61K45/06; A61K47/68
Foreign References:
| KR101551306B1 | 2015-09-09 | |||
| KR20170027312A | 2017-03-09 | |||
| US20150266959A1 | 2015-09-24 | |||
| KR101551306B1 | 2015-09-09 |
Other References:
HANSEN, W.: "Neuropilin 1 deficiency on CD 4+ Foxp3+ regulatory T cells impairs mouse melanoma growth", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 209, no. 11, 22 October 2012 (2012-10-22), pages 2001 - 2016, XP055673516, ISSN: 0022-1007 , DOI: 10.1084/jem.20111497
KIM, Y.-J. ET AL.: "Immunoglobulin Fc-fused, neuropilin-1-specific peptide shows efficient tumor tissue penetration and inhibits tumor growth via anti-angiogenesis", JOURNAL OF CONTROLLED RELEASE, vol. 216, 2015, XP055544043, DOI: 10.1016/j.jconrel.2015.08.016
See also references of EP 3680250A4
KIM, Y.-J. ET AL.: "Immunoglobulin Fc-fused, neuropilin-1-specific peptide shows efficient tumor tissue penetration and inhibits tumor growth via anti-angiogenesis", JOURNAL OF CONTROLLED RELEASE, vol. 216, 2015, XP055544043, DOI: 10.1016/j.jconrel.2015.08.016
See also references of EP 3680250A4
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
Download PDF: