Title:
COMPOSITION FOR SKIN WHITENING COMPRISING FRACTION OF INULA HELENIUM EXTRACT OR COMPOUND ISOLATED THEREFROM AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2020/235727
Kind Code:
A1
Abstract:
The present invention relates to a cosmetic composition for skin whitening comprising a hexane fraction of an Inula helenium extract, or an alantolactone or isoalantolactone compound isolated therefrom as an active ingredient. The fraction or compound according to the present invention inhibits melanin synthesis, and the compound of the present invention exhibits an effect of inhibiting mRNA or protein expression of a microphthalmia-associated transcription factor (MITF) which is a melanin synthesis promoting factor, tyrosinase, tyrosinase related protein 1, or tyrosinase related protein 2, and thus can be effectively used as a cosmetic composition for skin whitening, a pharmaceutical composition, or a functional health food.
Inventors:
KIM YEONG SHIK (KR)
KANG SAM SIK (KR)
KO HYEJIN (KR)
SONG KWANGHO (KR)
KANG SAM SIK (KR)
KO HYEJIN (KR)
SONG KWANGHO (KR)
Application Number:
PCT/KR2019/006211
Publication Date:
November 26, 2020
Filing Date:
May 23, 2019
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
A61K8/9789; A23L33/105; A61K8/49; A61K31/343; A61K36/28; A61P17/00; A61Q19/02
Domestic Patent References:
| WO2015043907A1 | 2015-04-02 |
Foreign References:
| KR20170048904A | 2017-05-10 | |||
| KR20150101393A | 2015-09-03 | |||
| CN101623312A | 2010-01-13 | |||
| KR20040107185A | 2004-12-20 | |||
| KR20190103897A | 2019-09-05 |
Other References:
GOKBULUT, A.: "ISOLATION AND QUANTIFICATION OF ALANTOLACTONE/ ISOALANTOLACTONE FROM THE ROOTS OF INULA HELENIUM SUBSP . TURCORACEMOSA", TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 10, no. 3, 2013, pages 447 - 452, XP055762937
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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