Title:
COMPOSITION FOR STRENGTHENING TISSUE REGENERATIVE POWER OF STEM CELL HAVING PTEN
Document Type and Number:
WIPO Patent Application WO/2012/121577
Kind Code:
A3
Abstract:
The present invention relates to a composition for strengthening the tissue regenerative power of a stem cell, the composition including PTEN, a kit for tissue regeneration, method for preparing a stem cell having strengthened tissue regenerative power using PTEN, and a method for regenerating a tissue. In addition, the present invention relates to a method for restoring a stem cell to a previous passage status using PTEN, a method for delaying the aging of a stem cell, and a composition for rejuvenating a stem cell, the composition including PTEN. The present invention resolves the problem of the decrease in the tissue regenerative power, auto regenerative power, and differentiation potency, which occurs due to an increase in the passage frequency, and secures multiple high quality stem cells outside the body.
Inventors:
LEE SEUNG JIN (KR)
JUNG MI RA (KR)
SHIM IN KYUNG (KR)
PARK YOON JEONG (KR)
KIM JONG SEOK (KR)
YANG YOUNG IL (KR)
CHUNG HYE JIN (KR)
JUNG MI RA (KR)
SHIM IN KYUNG (KR)
PARK YOON JEONG (KR)
KIM JONG SEOK (KR)
YANG YOUNG IL (KR)
CHUNG HYE JIN (KR)
Application Number:
PCT/KR2012/001795
Publication Date:
December 20, 2012
Filing Date:
March 12, 2012
Export Citation:
Assignee:
UNIV EWHA IND COLLABORATION (KR)
LEE SEUNG JIN (KR)
JUNG MI RA (KR)
SHIM IN KYUNG (KR)
PARK YOON JEONG (KR)
KIM JONG SEOK (KR)
YANG YOUNG IL (KR)
CHUNG HYE JIN (KR)
LEE SEUNG JIN (KR)
JUNG MI RA (KR)
SHIM IN KYUNG (KR)
PARK YOON JEONG (KR)
KIM JONG SEOK (KR)
YANG YOUNG IL (KR)
CHUNG HYE JIN (KR)
International Classes:
C07K19/00; C12N5/074
Other References:
ROSSI, D. J. ET AL.: "Pten, tumorigenesis, and stem cell self-renewal", CELL., vol. 125, no. 2, 21 April 2006 (2006-04-21), pages 229 - 231
CHEUNG, A. M. ET AL.: "PTEN in the haematopoietic system and its therapeutic indications", TRENDS IN MOLECULAR MEDICINE., vol. 12, no. 11, 25 September 2006 (2006-09-25), pages 503 - 505
YILMAZ, O. H. ET AL.: "Pten dependence distiguishes haematopoietic stem cells from leukemia-initiating cells", NATURE., vol. 441, no. 7092, 5 April 2006 (2006-04-05), pages 475 - 482
PARDAL, R. ET AL.: "Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors", COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY., vol. 70, 2005, pages 177 - 185
CHEUNG, A. M. ET AL.: "PTEN in the haematopoietic system and its therapeutic indications", TRENDS IN MOLECULAR MEDICINE., vol. 12, no. 11, 25 September 2006 (2006-09-25), pages 503 - 505
YILMAZ, O. H. ET AL.: "Pten dependence distiguishes haematopoietic stem cells from leukemia-initiating cells", NATURE., vol. 441, no. 7092, 5 April 2006 (2006-04-05), pages 475 - 482
PARDAL, R. ET AL.: "Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors", COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY., vol. 70, 2005, pages 177 - 185
Attorney, Agent or Firm:
SON, Min (6th Floor City Air Tower, 36, Teheran-ro 87 gil, Samsung-dong, Gangnam-gu, Seoul 135-973, KR)
Download PDF:
Claims: