Title:
COMPOSITION FOR SUPPRESSING ADIPOCYTE DIFFERENTIATION AND METHOD FOR SCREENING SUPPRESSIVE MATERIAL AGAINST ADIPOCYTE DIFFERENTIATION
Document Type and Number:
WIPO Patent Application WO/2018/004173
Kind Code:
A1
Abstract:
Disclosed in the specification are a composition comprising a suppressive material against SRBC expression or activity as an effective ingredient and a method for screening a suppressive material against adipocyte differentiation. A composition comprising a suppressive material against SRBC expression or activity as an effective ingredient according to an aspect of the present invention suppresses the differentiation of adipocytes and can be thus used for obesity prevention or alleviation. In addition, a method for screening a suppressive material against adipocyte differentiation according to an aspect of the present invention can screen a suppressive material against adipocyte differentiation simply, quickly, and effectively by treating dermal adipocytes with a test material and examining a relative expression level of an SRBC gene.
Inventors:
PARK PIL JOON (KR)
CHO SI YOUNG (KR)
LEE TAE RYONG (KR)
CHO EUN-GYUNG (KR)
CHO SI YOUNG (KR)
LEE TAE RYONG (KR)
CHO EUN-GYUNG (KR)
Application Number:
PCT/KR2017/006451
Publication Date:
January 04, 2018
Filing Date:
June 20, 2017
Export Citation:
Assignee:
AMOREPACIFIC CORP (KR)
International Classes:
A61K48/00; A23L33/13; A61K8/60; A61Q19/00; C12Q1/68
Other References:
MCMAHON, K. A. ET AL.: "SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function", THE EMBO JOURNAL, vol. 28, no. 8, 2009, pages 1001 - 1015, XP055600897, DOI: 10.1038/emboj.2009.46
BLOUIN, C. M.: "Regulated association of caveolins to lipid droplets during differentiation of 3T3-L1 adipocytes", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, pages 331 - 335, XP025495734, DOI: doi:10.1016/j.bbrc.2008.08.154
MEI, BAISONG ET AL.: "Only the large soluble form of preadipocyte factor-1 (Pref-1), but not the small soluble and membrane forms, inhibits adipocyte differentiation: role of alternative splicing", BIOCHEMICAL JOURNAL, vol. 364, no. 1, 15 May 2002 (2002-05-15), pages 137 - 144, XP055600900, DOI: 10.1042/bj3640137
BLOUIN, CEDRIC. M.: "Lipid droplet analysis in caveolin-deficient adipocytes: alterations in surface phospholipid composition and maturation defects", JOURNAL OF LIPID RESEARCH, vol. 51, no. 5, 2010, pages 945 - 956, XP055600903, DOI: 10.1194/jlr.M001016Cit
BRIAND, N.: "Caveolin-1 expression and cavin stability regulate caveolae dynamics in adipocyte lipid store fluctuation", DIABETES, vol. 63, no. 12, 2014, pages 4032 - 4044, XP055600907, DOI: 10.2337/db13-1961
BLOUIN, C. M.: "Regulated association of caveolins to lipid droplets during differentiation of 3T3-L1 adipocytes", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, pages 331 - 335, XP025495734, DOI: doi:10.1016/j.bbrc.2008.08.154
MEI, BAISONG ET AL.: "Only the large soluble form of preadipocyte factor-1 (Pref-1), but not the small soluble and membrane forms, inhibits adipocyte differentiation: role of alternative splicing", BIOCHEMICAL JOURNAL, vol. 364, no. 1, 15 May 2002 (2002-05-15), pages 137 - 144, XP055600900, DOI: 10.1042/bj3640137
BLOUIN, CEDRIC. M.: "Lipid droplet analysis in caveolin-deficient adipocytes: alterations in surface phospholipid composition and maturation defects", JOURNAL OF LIPID RESEARCH, vol. 51, no. 5, 2010, pages 945 - 956, XP055600903, DOI: 10.1194/jlr.M001016Cit
BRIAND, N.: "Caveolin-1 expression and cavin stability regulate caveolae dynamics in adipocyte lipid store fluctuation", DIABETES, vol. 63, no. 12, 2014, pages 4032 - 4044, XP055600907, DOI: 10.2337/db13-1961
Attorney, Agent or Firm:
KIM, Sun-young (KR)
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