COMPOSITION THAT CONTAINS RING-SHAPED DIPEPTIDE AND INHIBITS SERUM CARNOSINASE

Title:

COMPOSITION THAT CONTAINS RING-SHAPED DIPEPTIDE AND INHIBITS SERUM CARNOSINASE

Document Type and Number:

WIPO Patent Application WO2017010537

Kind Code:

A1

Abstract:

Provided are a carnosine dipeptidase 1 inhibitor composition, a use for said composition in order to inhibit carnosine dipeptidase 1, and a method for inhibiting carnosine dipeptidase 1. The present invention demonstrates the discovery of a specific ring-shaped dipeptide or salt thereof exhibiting an inhibitory activity against carnosine dipeptidase 1, and thus, provides a novel and effective means that contributes to the prevention or amelioration of a cognitive function decline or the like.

Inventors:

FUKIZAWA SHINYA (JP)
WATANABE HIROSHI (JP)
ABE KEIICHI (JP)

Application Number:

PCT/JP2016/070796

Publication Date:

January 19, 2017

Filing Date:

July 14, 2016

Export Citation:

Click for automatic bibliography generation Help

Assignee:

SUNTORY HOLDINGS LTD (JP)

International Classes:

A61K38/00; A61P3/10; A61P25/00; A61P25/28; A61P29/00; A61P37/04; A61P39/06

Foreign References:

JP2011068652A	2011-04-07
JP5690028B1	2015-03-25
JP2010166911A	2010-08-05

Other References:

GRAZ C.J.M. ET AL.: "Cyclic Dipeptides in the Induction of Maturation for Cancer Therapy", J. PHARM. PHARMACOL., vol. 52, no. 1, 2000, pages 75 - 82, XP055345984
BELLEZZA I. ET AL.: "Neuroinflammation and endoplasmic reticulum stress are coregulated by cyclo(His-Pro) to prevent LPS neurotoxicity", THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, vol. 51, 2014, pages 159 - 169, XP029026619

Attorney, Agent or Firm:

ONO, Shinjiro et al. (JP)

Download PDF:

View/Download PDF PDF Help

Previous Patent: COOLING DEVICE

Next Patent: COMPOSITION THAT CONTAINS PLANT- OR ANIMAL-DERIVED PEPTIDE AND INHIBITS SERUM CARNOSINASE