COMPOSITION THAT RECOGNIZES ANTIBODIES STEMMING FROM IMMUNE-MEDIATED PERIPHERAL NEUROPATHY AND USE FOR SAID COMPOSITION

Title:

COMPOSITION THAT RECOGNIZES ANTIBODIES STEMMING FROM IMMUNE-MEDIATED PERIPHERAL NEUROPATHY AND USE FOR SAID COMPOSITION

Document Type and Number:

WIPO Patent Application WO/2014/136974

Kind Code:

A1

Abstract:

Sugar-chain-immobilized fluorescent nanoparticles that allow quick and convenient detection of ganglioside-binding autoantibodies in blood serum from immune-mediated peripheral neuropathy patients are provided, as is a use for said sugar-chain-immobilized fluorescent nanoparticles. These sugar-chain-immobilized fluorescent nanoparticles contain the following: sugar-chain ligand complexes comprising sugar chains, including ganglioside-derived sugar chains, and a prescribed linker compound that has a hydrocarbon chain or the like on the main chain thereof; and fluorescent nanoparticles that have a prescribed core-shell structure. These sugar-chain-immobilized fluorescent nanoparticles are obtained by immobilizing the abovementioned sugar chains.

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Inventors:

SUDA YASUO (JP)
WAKAO MASAHIRO (JP)
ISHIDA HIDEHARU (JP)
YUKI NOBUHIRO (SG)

Application Number:

PCT/JP2014/056073

Publication Date:

September 12, 2014

Filing Date:

March 07, 2014

Export Citation:

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Assignee:

SUDX BIOTEC CORP (JP)
NAT UNIV CORP KAGOSHIMA (JP)
NAT UNIVERSITY CORP GIFU UNIVERSITY (JP)

International Classes:

G01N33/553; B82Y5/00; B82Y40/00; G01N33/53; G01N33/533

Foreign References:

JP2011209282A	2011-10-20
JP2008105978A	2008-05-08
JP2010122011A	2010-06-03
JPH11142404A	1999-05-28
JP2013040970A	2013-02-28
US20050130240A1	2005-06-16
US20060068506A1	2006-03-30
US20080039816A1	2008-02-14

Other References:

YUKI N ET AL.: "Animal model of axonal Guillain- Barre' syndrome induced by sensitization with GM1 ganglioside", ANN NEUROL, vol. 9, no. 6, pages 712 - 720

Attorney, Agent or Firm:

HARAKENZO WORLD PATENT & TRADEMARK (JP)
Patent business corporation HARAKENZO WORLD PATENT & TRADEMARK (JP)

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