Title:
COMPOSITION FOR TOPICAL USE
Document Type and Number:
WIPO Patent Application WO/2014/168228
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a pregabalin-containing composition that can produce satisfactory drug efficacy through topical administration. This composition is characterized in that the composition is one for topical application to the skin, the pregabalin is contained in a water-containing base, and the pregabalin content is 0.2-3 wt% with respect to total composition weight. The composition exhibits satisfactory drug efficacy despite the low pregabalin content (3 wt% or less) and the fact that pregabalin is the sole active ingredient. The pregabalin is preferably present in a water-dissolved form, and the form of the composition is preferably a solution lotion, emulsion lotion, spray, gel, water-in-oil type cream, or oil-in-water type cream.
Inventors:
KIDO HIROKO (JP)
KATAKUSE MAYAKO (JP)
HORISAWA EIJIRO (JP)
NARUMI FUMINORI (JP)
KATAKUSE MAYAKO (JP)
HORISAWA EIJIRO (JP)
NARUMI FUMINORI (JP)
Application Number:
PCT/JP2014/060453
Publication Date:
October 16, 2014
Filing Date:
April 11, 2014
Export Citation:
Assignee:
MARUHO KK (JP)
International Classes:
A61K31/197; A61K9/06; A61K9/08; A61K9/10; A61K31/195; A61K47/04; A61P19/02; A61P25/00; A61P25/04; A61P29/00
Domestic Patent References:
| WO2010036937A1 | 2010-04-01 | |||
| WO2003066040A1 | 2003-08-14 | |||
| WO2005089872A2 | 2005-09-29 |
Other References:
PLAZA-VILLEGAS F. ET AL.: "Topical pregabalin and diclofenac for the treatment of neuropathic orofacial pain in rats", ORAL SURG ORAL MED ORAL PATHOL ORAL RADIOL, vol. 114, no. 4, 2012, pages 449 - 56
BHATIA,C. ET AL.: "FORMULATION AND EVALUATION OF TRANSDERMAL PATCH OF PREGABALIN", IJPSR, vol. 3, no. 2, 2012, pages 569 - 575
ACHRAI,B. ET AL.: "Solubilization of Gabapentin into HII Mesophases", J. PHYS. CHEM. B, vol. 115, 2011, pages 825 - 835, XP055271318, DOI: doi:10.1021/jp108801d
BHATIA,C. ET AL.: "FORMULATION AND EVALUATION OF TRANSDERMAL PATCH OF PREGABALIN", IJPSR, vol. 3, no. 2, 2012, pages 569 - 575
ACHRAI,B. ET AL.: "Solubilization of Gabapentin into HII Mesophases", J. PHYS. CHEM. B, vol. 115, 2011, pages 825 - 835, XP055271318, DOI: doi:10.1021/jp108801d
Attorney, Agent or Firm:
MINORI Patent Profession Corporation (JP)
Patent business corporation Minori patent firm (JP)
Patent business corporation Minori patent firm (JP)
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