Title:
COMPOSITION FOR TREATING ALK INHIBITOR-RESISTANT NON-SMALL CELL LUNG CANCER COMPRISING CDA INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/128722
Kind Code:
A1
Abstract:
The present invention relates to a composition for treating ALK inhibitor-resistant non-small cell lung cancer comprising a cysteine deaminase (CDA) inhibitor and, more specifically, to a composition for treating ALK inhibitor-resistant non-small cell lung cancer which inhibits the expression or activity of CDA to inhibit the proliferation, migration, and invasion of ALK inhibitor-resistant non-small cell lung cancer and exhibit anticancer activity.
Inventors:
KIM MI RANG (KR)
HEO HAE JEONG (KR)
HAAM KEE OK (KR)
HEO HAE JEONG (KR)
HAAM KEE OK (KR)
Application Number:
PCT/KR2023/000031
Publication Date:
July 06, 2023
Filing Date:
January 02, 2023
Export Citation:
Assignee:
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
International Classes:
A61K48/00; A23L33/13; A61K31/7068; A61K31/713; A61K45/06; A61P35/00; C12Q1/6886; G01N33/50
Foreign References:
| KR20180120565A | 2018-11-06 | |||
| KR20190104530A | 2019-09-10 | |||
| KR20170085619A | 2017-07-25 | |||
| US20130156796A1 | 2013-06-20 |
Other References:
HEO HAEJEONG, KIM JONG-HWAN, LIM HYUN JUNG, KIM JEONG-HWAN, KIM MISO, KOH JAEMOON, IM JOO-YOUNG, KIM BO-KYUNG, WON MISUN, PARK JI-: "Targeting CDA-Directed Metabolism With 5-Formyl-2'-Deoxycytidine For ALK Inhibitor–Resistant Lung Cancer Therapy", RESEARCH SQUARE, 24 November 2021 (2021-11-24), XP093074313, [retrieved on 20230816], DOI: 10.21203/rs.3.rs-1110449/v1
HEO HAEJEONG, KIM JONG-HWAN, LIM HYUN JUNG, KIM JEONG-HWAN, KIM MISO, KOH JAEMOON, IM JOO-YOUNG, KIM BO-KYUNG, WON MISUN, PARK JI-: "DNA methylome and single-cell transcriptome analyses reveal CDA as a potential druggable target for ALK inhibitor–resistant lung cancer therapy", EXPERIMENTAL & MOLECULAR MEDICINE, vol. 54, no. 8, pages 1236 - 1249, XP093074314, DOI: 10.1038/s12276-022-00836-7
HEO HAEJEONG, KIM JONG-HWAN, LIM HYUN JUNG, KIM JEONG-HWAN, KIM MISO, KOH JAEMOON, IM JOO-YOUNG, KIM BO-KYUNG, WON MISUN, PARK JI-: "DNA methylome and single-cell transcriptome analyses reveal CDA as a potential druggable target for ALK inhibitor–resistant lung cancer therapy", EXPERIMENTAL & MOLECULAR MEDICINE, vol. 54, no. 8, pages 1236 - 1249, XP093074314, DOI: 10.1038/s12276-022-00836-7
Attorney, Agent or Firm:
LEE, Hee Sook (KR)
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