Title:
COMPOSITION FOR TREATING CANCER DISEASE, COMPRISING EXTRACELLULAR VESICLE DERIVED FROM NATURAL KILLER CELLS WITH SURFACE EXPRESSION OF CYTOKINE AND ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2024/072052
Kind Code:
A1
Abstract:
The present invention relates to a composition for treating a cancer disease, comprising an extracellular vesicle derived from natural killer cells with surface expression of cytokine and an antibody. By expressing IL-15 and a cancer cell-specific antibody on the surface of human natural killer cells, it is possible to provide an extracellular vesicle that can exhibit strong cytotoxic activity specifically against cancer cells. The extracellular vesicle can be provided as a new anticancer agent that is safe for the human body and exhibits an excellent anticancer effect. In addition, the extracellular vesicle of the present invention can be used to deliver drugs or bioactive substances to specific cancer cells by encapsulating the drugs or bioactive substances having a therapeutic effect on cancer therein, and thus can be provided as a new means of treating cancer.
Inventors:
YEA KYUNG MOO (KR)
BAEK MOON-CHANG (KR)
KANG SUNG-MIN (KR)
BAEK MOON-CHANG (KR)
KANG SUNG-MIN (KR)
Application Number:
PCT/KR2023/014935
Publication Date:
April 04, 2024
Filing Date:
September 26, 2023
Export Citation:
Assignee:
DAEGU GYEONGBUK INST SCIENCE & TECH (KR)
KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR)
KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR)
International Classes:
A61K35/17; A61K9/50; A61K38/20; A61K39/00; A61K39/395; A61P35/00
Foreign References:
| KR20220031505A | 2022-03-11 | |||
| US20200405640A1 | 2020-12-31 |
Other References:
WATSON DIONYSIOS C.; BAYIK DEFNE; SRIVATSAN AVINASH; BERGAMASCHI CRISTINA; VALENTIN ANTONIO; NIU GANG; BEAR JENIFER; MONNINGER MIT: "Efficient production and enhanced tumor delivery of engineered extracellular vesicles", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 105, 6 July 2016 (2016-07-06), AMSTERDAM, NL , pages 195 - 205, XP029697461, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2016.07.003
ENOMOTO YUTAKA; LI PENG; JENKINS LISA M.; ANASTASAKIS DIMITRIOS; LYONS GAELYN C.; HAFNER MARKUS; LEONARD WARREN J.: "Cytokine-enhanced cytolytic activity of exosomes from NK Cells", CANCER GENE THERAPY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 29, no. 6, 27 July 2021 (2021-07-27), New York, pages 734 - 749, XP037893753, ISSN: 0929-1903, DOI: 10.1038/s41417-021-00352-2
DIONYSIOS C. WATSON, YUNG BRYANT C., BERGAMASCHI CRISTINA, CHOWDHURY BHABADEB, BEAR JENIFER, STELLAS DIMITRIS, MORALES-KASTRESANA : "Scalable, cGMP-compatible purification of extracellular vesicles carrying bioactive human heterodimeric IL-15/lactadherin complexes", JOURNAL OF EXTRACELLULAR VESICLES, vol. 7, no. 1, 1 January 2018 (2018-01-01), pages 1 - 16, XP055674284, DOI: 10.1080/20013078.2018.1442088
ENOMOTO YUTAKA; LI PENG; JENKINS LISA M.; ANASTASAKIS DIMITRIOS; LYONS GAELYN C.; HAFNER MARKUS; LEONARD WARREN J.: "Cytokine-enhanced cytolytic activity of exosomes from NK Cells", CANCER GENE THERAPY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 29, no. 6, 27 July 2021 (2021-07-27), New York, pages 734 - 749, XP037893753, ISSN: 0929-1903, DOI: 10.1038/s41417-021-00352-2
DIONYSIOS C. WATSON, YUNG BRYANT C., BERGAMASCHI CRISTINA, CHOWDHURY BHABADEB, BEAR JENIFER, STELLAS DIMITRIS, MORALES-KASTRESANA : "Scalable, cGMP-compatible purification of extracellular vesicles carrying bioactive human heterodimeric IL-15/lactadherin complexes", JOURNAL OF EXTRACELLULAR VESICLES, vol. 7, no. 1, 1 January 2018 (2018-01-01), pages 1 - 16, XP055674284, DOI: 10.1080/20013078.2018.1442088
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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